ArticleVirus genes2008
Characterization of AcMNPV with a deletion of ac68 gene.
Article in Virus genes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- A sensitive assay for scrutiny of Autographa californica multiple nucleopolyhedrovirus genes using CRISPR-Cas9.Applied microbiology and biotechnology · 2023Article
- BmNPV Orf 65 (Bm65) Is Identified as an Endonuclease Directly Facilitating UV-Induced DNA Damage Repair.Journal of virology · 2022Article
- Functional Regulation of an Autographa californica Nucleopolyhedrovirus-Encoded MicroRNA, AcMNPV-miR-1, in Baculovirus Replication.Journal of virology · 2016Article
- Bm65 is essential for the propagation of Bombyx mori nucleopolyhedrovirus.Current microbiology · 2013Article
- Disruption of Bombyx mori nucleopolyhedrovirus ORF71 (Bm71) results in inefficient budded virus production and decreased virulence in host larvae.Virus genes · 2012Article
- Analysis of the autographa californica multiple nucleopolyhedrovirus overlapping gene pair lef3 and ac68 reveals that AC68 is a per os infectivity factor and that LEF3 is critical, but not essential, for virus replication.Journal of virology · 2012Article
- Baculovirus-encoded protein BV/ODV-E26 determines tissue tropism and virulence in lepidopteran insects.Journal of virology · 2012Article
- Baculovirus: molecular insights on their diversity and conservation.International journal of evolutionary biology · 2011Article
- Effect of ac68 knockout and lef3 leading sequence disruption on viral propagation.Current microbiology · 2011Article
- Identification of a domain of the baculovirus Autographa californica multiple nucleopolyhedrovirus single-strand DNA-binding protein LEF-3 essential for viral DNA replication.Journal of virology · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orf68 (ac68) of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is a highly conserved gene that codes a predicted 192-amino acid protein, but its function remains unknown. Results of the current study showed that ac68 was transcribed from 3 to 96 h and the protein was detected from 36 to 96 h post infection. An ac68 knockout bacmid was generated to investigate the role of the gene in baculovirus life cycle. Analyses of the production of infectious budded virus, occlusion bodies, and the formation of nucleocapsids revealed that there was no difference between the infection patterns of the mutant and its parent virus, or the ac68 repair virus. Bioassay with Trichoplusia ni demonstrated that deletion of ac68 did not affect AcMNPV infectivity, but extended LT(50) to a longer value. Taken together, our results indicated that the deletion did not affect viral propagation both in vitro and in vivo, but deletion of the gene may affect the virulence in T. ni larvae.
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