ArticlePLoS genetics2008
HOXA13 Is essential for placental vascular patterning and labyrinth endothelial specification.
Article in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 100 citations in OpenAlex.
- Dll4 assembles the umbilical cord and placental vasculature.JCI insight · 2026Article
- Feto-placental blood vessel development.Development (Cambridge, England) · 2025Review
- The causal effects of placental weight on atherosclerotic cardiovascular disease: a Mendelian randomization and mediation analysis.Archives of medical science : AMS · 2025Article
- Spatial multiomic landscape of the human placenta at molecular resolution.Nature medicine · 2024Article
- Placental extracellular vesicles promote cardiomyocyte maturation and fetal heart development.Communications biology · 2024Article
- Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse model harboring patient-derived Setd2 mutation.Frontiers of medicine · 2024Article
- Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors and is Required for Placenta Morphogenesis and Vasculature Formation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Molecular regulators of defective placental and cardiovascular development in fetal growth restriction.Clinical science (London, England : 1979) · 2024Review
- Hypoxia exposure blunts angiogenic signaling and upregulates the antioxidant system in endothelial cells derived from elephant seals.BMC biology · 2024Article
- Serotonin Transporter-dependent Histone Serotonylation in Placenta Contributes to the Neurodevelopmental Transcriptome.Journal of molecular biology · 2024Article
- Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome.bioRxiv : the preprint server for biology · 2023Article
- Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor.eLife · 2023Article
- HOXA13 serves as a biomarker to predict neoadjuvant therapy efficacy in advanced colorectal cancer patients.Acta biochimica et biophysica Sinica · 2022Article
- Mouse placenta fetal macrophages arise from endothelial cells outside the placenta.Developmental cell · 2022Article
- Apelin Alleviates Meniscus Endothelial Cell Apoptosis in Osteoarthritis.Disease markers · 2022Article
- HOX genes in stem cells: Maintaining cellular identity and regulation of differentiation.Frontiers in cell and developmental biology · 2022Review
- Mapping cis-regulatory elements in the midgestation mouse placenta.Scientific reports · 2021Article
- Pathogenesis of Anorectal Malformations in Retinoic Acid Receptor Knockout Mice Studied by HREM.Biomedicines · 2021Article
- Analysis of Placental Arteriovenous Formation Reveals New Insights Into Embryos With Congenital Heart Defects.Frontiers in genetics · 2021Article
- The transcriptional regulator CCCTC-binding factor limits oxidative stress in endothelial cells.The Journal of biological chemistry · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
In eutherian mammals, embryonic growth and survival is dependent on the formation of the placenta, an organ that facilitates the efficient exchange of oxygen, nutrients, and metabolic waste between the maternal and fetal blood supplies. Key to the placenta's function is the formation of its vascular labyrinth, a series of finely branched vessels whose molecular ontogeny remains largely undefined. In this report, we demonstrate that HOXA13 plays an essential role in labyrinth vessel formation. In the absence of HOXA13 function, placental endothelial cell morphology is altered, causing a loss in vessel wall integrity, edema of the embryonic blood vessels, and mid-gestational lethality. Microarray analysis of wild-type and mutant placentas revealed significant changes in endothelial gene expression profiles. Notably, pro-vascular genes, including Tie2 and Foxf1, exhibited reduced expression in the mutant endothelia, which also exhibited elevated expression of genes normally expressed in lymphatic or sinusoidal endothelia. ChIP analysis of HOXA13-DNA complexes in the placenta confirmed that HOXA13 binds the Tie2 and Foxf1 promoters in vivo. In vitro, HOXA13 binds sequences present in the Tie2 and Foxf1 promoters with high affinity (K(d) = 27-42 nM) and HOXA13 can use these bound promoter regions to direct gene expression. Taken together, these findings demonstrate that HOXA13 directly regulates Tie2 and Foxf1 in the placental labyrinth endothelia, providing a functional explanation for the mid-gestational lethality exhibited by Hoxa13 mutant embryos as well as a novel transcriptional program necessary for the specification of the labyrinth vascular endothelia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.