ReviewGenes & development2008
Molecular determinants of brown adipocyte formation and function.
Review in Genes & development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 166 citations in OpenAlex.
- VEGFR-dependent signaling contributes to postnatal brown adipose tissue development in Syrian hamsters.The journal of physiological sciences : JPS · 2026Article
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- DPP-IV and FAS inhibitory peptides: therapeutic alternative against diabesity.Journal of diabetes and metabolic disorders · 2025Review
- SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice.Cell death and differentiation · 2025Article
- Angiotensin II Inhibits Adipogenic Differentiation and Promotes Mature Adipocyte Browning through the Corepressor CtBP1.Biomedicines · 2022Article
- Reproductive and endocrine effects of artemisinin, piperaquine, and artemisinin-piperaquine combination in rats.BMC complementary medicine and therapies · 2022Article
- Effects of maternal undernutrition during late pregnancy on the regulatory factors involved in growth and development in ovine fetal perirenal brown adipose tissue.Animal bioscience · 2022Article
- The Vasoactive Effect of Perivascular Adipose Tissue and Hydrogen Sulfide in Thoracic Aortas of Normotensive and Spontaneously Hypertensive Rats.Biomolecules · 2022Article
- Antibiotic Azithromycin inhibits brown/beige fat functionality and promotes obesity in human and rodents.Theranostics · 2022Article
- PRDM16 Regulating Adipocyte Transformation and Thermogenesis: A Promising Therapeutic Target for Obesity and Diabetes.Frontiers in pharmacology · 2022Review
- Comparative Proteomic Analysis of tPVAT during Ang II Infusion.Biomedicines · 2021Article
- Development of CIDEA reporter mouse model and its application for screening thermogenic drugs.Scientific reports · 2021Article
- Effect of Acupoint Embedding on Serum Leptin and Hypothalamus Leptin Receptor Expression in Rats with Simple Obesity.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Article
- Purified Gymnemic Acids fromNutrients · 2020Article
- Rosiglitazone-induced changes in the oxidative stress metabolism and fatty acid composition in relation with trace element status in the primary adipocytes.Journal of medical biochemistry · 2020Article
- Epigenetic dynamics of the thermogenic gene program of adipocytes.The Biochemical journal · 2020Review
- Article
- Long Non-Coding RNAs in Brown Adipose Tissue.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
29 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Humans contain essentially two types of adipose tissue: brown adipose tissue (BAT) and white adipose tissue (WAT). The function of WAT is to store fat while that of BAT is to burn fat for heat production. A potential strategy to combat obesity and its related disorders is to induce the conversion of WAT into BAT. In this issue of Genes & Development, Kajimura and colleagues (pp. 1397-1409) have identified a mechanism by which PRDM16, the principal regulator of brown adipocyte formation and function, can simultaneously induce BAT gene expression, while suppressing WAT gene expression. The studies suggest that PRDM16 and its associated coregulators PPARgamma coactivator-1alpha (PGC-1alpha) and C-terminal-binding protein 1/2 (CtBP1/2), which control the switch from WAT to BAT, are potential targets for development of obesity-related therapeutics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.