ArticleJournal of virology1991
Induction of self-reactive T cells after murine coronavirus infection.
Article in Journal of virology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- The Incidence of Myocarditis and Pericarditis in Post COVID-19 Unvaccinated Patients-A Large Population-Based Study.Journal of clinical medicine · 2022Article
- Coronavirus-induced autoimmunity.Clinical immunology (Orlando, Fla.) · 2021Review
- Viral-induced suppression of self-reactive T cells: Lessons from neurotropic coronavirus-induced demyelination.Journal of neuroimmunology · 2017Review
- Self-reactive CD4(+) T cells activated during viral-induced demyelination do not prevent clinical recovery.Journal of neuroinflammation · 2015Article
- Annexin A2 on lung epithelial cell surface is recognized by severe acute respiratory syndrome-associated coronavirus spike domain 2 antibodies.Molecular immunology · 2010Article
- Antibody to severe acute respiratory syndrome (SARS)-associated coronavirus spike protein domain 2 cross-reacts with lung epithelial cells and causes cytotoxicity.Clinical and experimental immunology · 2005Article
- Transcriptome profile within the mouse central nervous system and activation of myelin-reactive T cells following murine coronavirus infection.Journal of neuroimmunology · 2005Article
- Viral induced demyelination.Brain pathology (Zurich, Switzerland) · 2001Review
- Article
- Mouse hepatitis virus A59-induced demyelination can occur in the absence of CD8+ T cells.Microbial pathogenesis · 1995Article
- Immunopathological aspects of coronavirus infections.Springer seminars in immunopathology · 1995Review
- Characterization of mouse hepatitis virus-specific cytotoxic T cells derived from the central nervous system of mice infected with the JHM strain.Journal of virology · 1993Article
- High frequency of cross-reactive cytotoxic T lymphocytes elicited during the virus-induced polyclonal cytotoxic T lymphocyte response.The Journal of experimental medicine · 1993Article
- Article
- Detection of coronavirus RNA and antigen in multiple sclerosis brain.Annals of neurology · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the mechanism of in vitro spontaneous lymphokine production by spleen cells from mice injected intraperitoneally with murine coronavirus stain JHM 1 month after infection, when infectious virus had already been cleared from the spleens. Removal of either CD4+ T cells or Ia+ antigen-presenting cells (APC) from the spleen cells abrogated interleukin-2 (IL-2) production. Addition of anti-CD4 or anti-Iad monoclonal antibodies to the culture suppressed IL-2 production. These results suggest that the response involved typical receptor-mediated activation of T cells. Surprisingly, reciprocal mixing experiments with a coculture of T cells from infected mice and APC from either infected or naive mice resulted in the production of IL-2. The absence of viral antigens in spleen cells 1 month after infection, as indicated by their inability to induce the proliferation of T-cell clones specific for the viral antigens, suggest that the T cells from mice 1 month after infection were not responding to the viral antigens. The inoculum components other than the virus did not induce this immune response. We also found that the frequency of self-reactive but not alloreactive IL-2-producing T cells in the spleens of infected mice was 3- to 10-fold higher than that in naive mice. These findings suggest that an increased frequency of self-reactive T cells which secrete IL-2 occurs following murine coronavirus infection. This may have important implications in the development of autoimmunelike phenomena following murine coronavirus infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.