ArticleThe Journal of biological chemistry2008
Potential molecular mechanism for c-Src kinase-mediated regulation of intestinal cell migration.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Maresin-2 promotes mucosal repair and has therapeutic potential when encapsulated in thermostable nanoparticles.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Transcriptome profiles discriminate between Gram-positive and Gram-negative sepsis in preterm neonates.Pediatric research · 2022Observational
- Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway.International journal of molecular sciences · 2021Article
- Alterative Expression and Localization of Profilin 1/VASPpS157 and Cofilin 1/VASPpS239 Regulates Metastatic Growth and Is Modified by DHA Supplementation.Molecular cancer therapeutics · 2016Article
- By moonlighting in the nucleus, villin regulates epithelial plasticity.Molecular biology of the cell · 2016Article
- Identification of Novel Candidate Genes for Early-Onset Colorectal Cancer Susceptibility.PLoS genetics · 2016Article
- Apical invasion of intestinal epithelial cells by Salmonella typhimurium requires villin to remodel the brush border actin cytoskeleton.Cell host & microbe · 2015Article
- CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells.Oncotarget · 2015Article
- PTP-PEST targets a novel tyrosine site in p120 catenin to control epithelial cell motility and Rho GTPase activity.Journal of cell science · 2014Article
- Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases.Biochemistry · 2014Article
- Enterocyte loss of polarity and gut wound healing rely upon the F-actin-severing function of villin.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Regulation of tumor cell migration by protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-,and threonine-rich sequence (PEST).Chinese journal of cancer · 2013Review
- Actin reorganization as the molecular basis for the regulation of apoptosis in gastrointestinal epithelial cells.Cell death and differentiation · 2012Article
- A TRIF-independent branch of TLR3 signaling.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- C-Src and c-Yes are two unlikely partners of spermatogenesis and their roles in blood-testis barrier dynamics.Advances in experimental medicine and biology · 2012Article
- Roles of hormones and signaling molecules in describing the relationship between obesity and colon cancer.Pathology oncology research : POR · 2011Review
- c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes.The international journal of biochemistry & cell biology · 2011Article
- ILK mediates the effects of strain on intestinal epithelial wound closure.American journal of physiology. Cell physiology · 2011Article
- Regulation of villin by wnt5a/ror2 signaling in human intestinal cells.Frontiers in physiology · 2011Article
- Genetic variability in EGFR, Src and HER2 and risk of colorectal adenoma and cancer.International journal of molecular epidemiology and genetics · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The ubiquitously expressed Src tyrosine kinases (c-Src, c-Yes, and c-Fyn) regulate intestinal cell growth and differentiation. Src activity is also elevated in the majority of malignant and premalignant tumors of the colon. The development of fibroblasts with the three ubiquitously expressed kinases deleted (SYF cells) has identified the role of Src proteins in the regulation of actin dynamics associated with increased cell migration and invasion. Despite this, unexpectedly nothing is known about the role of the individual Src kinases on intestinal cell cytoskeleton and/or cell migration. We have previously reported that villin, an epithelial cell-specific actin-modifying protein that regulates actin reorganization, cell morphology, cell migration, cell invasion, and apoptosis, is tyrosine-phosphorylated. In this report using the SYF cells reconstituted individually with c-Src, c-Yes, c-Fyn, and wild type or phosphorylation site mutants of villin, we demonstrate for the first time the absolute requirement for c-Src in villin-induced regulation of cell migration. The other major finding of our study is that contrary to previous reports, the nonreceptor tyrosine kinase, Jak3 (Janus kinase 3), does not regulate phosphorylation of villin or villin-induced cell migration and is, in fact, not expressed in intestinal epithelial cells. Further, we identify SHP-2 and PTP-PEST (protein-tyrosine phosphatase proline-, glutamate-, serine-, and threonine-rich sequence) as negative regulators of c-Src kinase and demonstrate a new function for these phosphatases in intestinal cell migration. Together, these data suggest that in colorectal carcinogenesis, elevation of c-Src or down-regulation of SHP-2 and/or PTP-PEST may promote cancer metastases and invasion by regulating villin-induced cell migration and cell invasion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.