ArticleGenomics2008
HapMap tagSNP transferability in multiple populations: general guidelines.
Article in Genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
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- HapMap-based study: CYP2A13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non-smokers.Thoracic cancer · 2019Article
- Type I Interferon Receptor Variants in Gene Regulatory Regions are Associated with Susceptibility to Cerebral Malaria in Malawi.The American journal of tropical medicine and hygiene · 2018Article
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- Shades of gray: a comparison of linkage disequilibrium between Hutterites and Europeans.Genetic epidemiology · 2010Article
- Genetic diversity in India and the inference of Eurasian population expansion.Genome biology · 2010Article
- Stable patterns of gene expression regulating carbohydrate metabolism determined by geographic ancestry.PloS one · 2009Article
- TagSNP transferability and relative loss of variability prediction from HapMap to an admixed population.Journal of biomedical science · 2009Article
- Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap-CEU populations.European journal of human genetics : EJHG · 2009Article
- Human genetic variation and its contribution to complex traits.Nature reviews. Genetics · 2009Review
- Genotype-imputation accuracy across worldwide human populations.American journal of human genetics · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Linkage disequilibrium (LD) has received much attention recently because of its value in localizing disease-causing genes. Due to the extensive LD between neighboring loci in the human genome, it is believed that a subset of the single nucleotide polymorphisms in a region (tagSNPs) can be selected to capture most of the remaining SNP variants. In this study, we examined LD patterns and HapMap tagSNP transferability in more than 300 individuals. A South Indian sample and an African Mbuti Pygmy population sample were included to evaluate the performance of HapMap tagSNPs in geographically distinct and genetically isolated populations. Our results show that HapMap tagSNPs selected with r(2) >= 0.8 can capture more than 85% of the SNPs in populations that are from the same continental group. Combined tagSNPs from HapMap CEU and CHB+JPT serve as the best reference for the Indian sample. The HapMap YRI are a sufficient reference for tagSNP selection in the Pygmy sample. In addition to our findings, we reviewed over 25 recent studies of tagSNP transferability and propose a general guideline for selecting tagSNPs from HapMap populations.
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