ArticleBrain research2008
Comparison of the ontogeny of the vesicular glutamate transporter 3 (VGLUT3) with VGLUT1 and VGLUT2 in the rat retina.
Article in Brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Fluorescent identification of axons, dendrites and soma of neuronal retinal ganglion cells with a genetic marker as a tool for facilitating the study of neurodegeneration.FASEB bioAdvances · 2025Article
- Rapid and efficient generation of a transplantable population of functional retinal ganglion cells from fibroblasts.Cell proliferation · 2024Article
- InducibleCells · 2023Article
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- Local synaptic integration enables ON-OFF asymmetric and layer-specific visual information processing in vGluT3 amacrine cell dendrites.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Generation of Functional Human Retinal Ganglion Cells with Target Specificity from Pluripotent Stem Cells by Chemically Defined Recapitulation of Developmental Mechanism.Stem cells (Dayton, Ohio) · 2017Article
- Diverse Central Projection Patterns of Retinal Ganglion Cells.Cell reports · 2017Article
- Enriched retinal ganglion cells derived from human embryonic stem cells.Scientific reports · 2016Article
- ON and OFF retinal ganglion cells differentially regulate serotonergic and GABAergic activity in the dorsal raphe nucleus.Scientific reports · 2016Article
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- Localization of diacylglycerol lipase alpha and monoacylglycerol lipase during postnatal development of the rat retina.Frontiers in neuroanatomy · 2014Article
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- Retinal input regulates the timing of corticogeniculate innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
- Genetic targeting and physiological features of VGLUT3+ amacrine cells.Visual neuroscience · 2011Article
- Article
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- Vesicular glutamate transporter 3 in age-dependent optic neuropathy.Molecular vision · 2011Article
- Evidence for a role of glutamate as an efferent transmitter in taste buds.BMC neuroscience · 2010Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Glutamate is the major excitatory neurotransmitter in the retina, and most glutamatergic neurons express one of the three known vesicular glutamate transporters (VGLUT1, 2, or 3). However, the expression profiles of these transporters vary greatly in the retina. VGLUT1 is expressed by photoreceptor and bipolar cell terminals, and VGLUT2 appears to be predominately expressed by ganglion cells, and perhaps Müller cells, cone photoreceptor terminals, and horizontal cells in some species. The discovery of a third vesicular glutamate transporter, VGLUT3, has brought about speculation concerning its role and function based on its expression in amacrine cells. To address this we studied the postnatal development of VGLUT3 from day 0 through adult in the rat retina, and compared this with the expression patterns of VGLUT1 and VGLUT2. VGLUT3 expression was restricted to a population of amacrine cells. Expression of VGLUT3 was first observed at postnatal day 10 (P10) in the soma and some processes, which extensively arborized in both the ON and OFF sublamina of the IPL by P15. In contrast, VGLUT1 and VGLUT2 expression appeared earlier than VGLUT3; with VGLUT1 initially detected at P5 in photoreceptor terminals and P6 in bipolar terminals, and VGLUT2 immunoreactivity initially detected at P0 in ganglion cell bodies, and remained prominent throughout all stages of development. Interestingly, VGLUT3 has extensive somatic expression throughout development, which could be involved in non-synaptic modulation by glutamate in developing retina, and could influence trophic and extra-synaptic neuronal signaling by glutamate in the inner retina.
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