ArticleBiochemical Society transactions2008
Mechanisms regulating targeting of recycling endosomes to the cleavage furrow during cytokinesis.
Article in Biochemical Society transactions, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- The midbody and midbody remnant: from cellular debris to signaling organelle with diagnostic and therapeutic potential.Molecular biology of the cell · 2025Review
- The dual functions of Rab11 and Rab35 GTPases-regulation of cell division and promotion of tumorigenicity.American journal of cancer research · 2021Review
- The Small GTPase Arf6: An Overview of Its Mechanisms of Action and of Its Role in Host⁻Pathogen Interactions and Innate Immunity.International journal of molecular sciences · 2019Review
- Organelle Inheritance Control of Mitotic Entry and Progression: Implications for Tissue Homeostasis and Disease.Frontiers in cell and developmental biology · 2019Review
- The functional interplay of Rab11, FIP3 and Rho proteins on the endosomal recycling pathway controls cell shape and symmetry.Small GTPases · 2018Review
- Rab GTPases and cell division.Small GTPases · 2018Review
- Polo kinase mediates the phosphorylation and cellular localization of Nuf/FIP3, a Rab11 effector.Molecular biology of the cell · 2017Article
- The neurotrophin receptor signaling endosome: Where trafficking meets signaling.Developmental neurobiology · 2017Review
- Article
- Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling.Developmental cell · 2015Article
- Synaptic Function of Rab11Fip5: Selective Requirement for Hippocampal Long-Term Depression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Rab family of GTPases.Methods in molecular biology (Clifton, N.J.) · 2015Review
- Biogenesis and function of the NGF/TrkA signaling endosome.International review of cell and molecular biology · 2015Review
- Souffle/Spastizin controls secretory vesicle maturation during zebrafish oogenesis.PLoS genetics · 2014Article
- LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes.Molecular biology of the cell · 2014Article
- Recycling endosome tubule morphogenesis from sorting endosomes requires the kinesin motor KIF13A.Cell reports · 2014Article
- Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells.Small GTPases · 2014Review
- A trapper keeper for TRAPP, its structures and functions.Cellular and molecular life sciences : CMLS · 2012Review
- GTPase networks in membrane traffic.Annual review of biochemistry · 2012Review
- Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Recently, recycling endosomes have emerged as a key components required for the successful completion of cytokinesis. Furthermore, FIP3 (family of Rab11-interacting protein 3), a Rab11 GTPase-binding protein, has been implicated in targeting the recycling endosomes to the midbody of dividing cells. Previously, we have shown that FIP3/Rab11-containing endosomes associate with centrosomes until anaphase, at which time they translocate to the cleavage furrow. At telophase, FIP3/Rab11-containing endosomes move from the furrow into the midbody, and this step is required for abscission. While several other proteins were implicated in regulating FIP3 targeting to the cleavage furrow, the mechanisms regulating the dynamics of FIP3-containing endosomes during mitosis have not been defined. To identify the factors regulating FIP3 targeting to the furrow, we used a combination of siRNA (small interfering RNA) screens and proteomic analysis to identify Cyk-4/MgcRacGAP (GTPase-activating protein) and kinesin I as FIP3-binding proteins. Furthermore, kinesin I mediates the transport of FIP3-containing endosomes to the cleavage furrow. Once in the furrow, FIP3 binds to Cyk-4 as part of centralspindlin complex and accumulates at the midbody. Finally, we demonstrated that ECT2 regulates FIP3 association with the centralspindlin complex. Thus we propose that kinesin I, in concert with centralspindlin complex, plays a role in temporal and spatial regulation of endosome transport to the cleavage furrow during cytokinesis.
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