ArticleJournal of clinical immunology2008
Genetic polymorphisms in the CD40 ligand gene and Kawasaki disease.
Article in Journal of clinical immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Recent advances in research on gene polymorphisms in Kawasaki disease.World journal of clinical pediatrics · 2025Review
- Associations of MMP9 polymorphism with the risk of severe pneumonia in a Southern Chinese children population.BMC infectious diseases · 2024Article
- Kawasaki Disease-Associated Cytokine Storm Syndrome.Advances in experimental medicine and biology · 2024Review
- Article
- Validation of genome-wide associated variants for Kawasaki disease in a Taiwanese case-control sample.Scientific reports · 2020Article
- Kawasaki disease: pathophysiology and insights from mouse models.Nature reviews. Rheumatology · 2020Review
- Lower CMV and EBV Exposure in Children With Kawasaki Disease Suggests an Under-Challenged Immune System.Frontiers in pediatrics · 2020Article
- Preventing coronary artery lesions in Kawasaki disease.Biomedical journal · 2017Review
- miRNA-145 inhibits VSMC proliferation by targeting CD40.Scientific reports · 2016Article
- Genetic polymorphism of SMAD5 is associated with Kawasaki disease.Pediatric cardiology · 2014Article
- The role of infection in Kawasaki syndrome.The Journal of infection · 2013Review
- Interleukin-21 receptor gene polymorphisms in kawasaki disease.Korean circulation journal · 2013Article
- CD40 Gene polymorphisms associated with susceptibility and coronary artery lesions of Kawasaki disease in the Taiwanese population.TheScientificWorldJournal · 2012Article
- Genetic polymorphisms in Kawasaki disease.Acta pharmacologica Sinica · 2011Review
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough some previous studies have reported that genetic and immunological factors play important roles in the pathogenesis of Kawasaki disease (KD), the etiological factors of this enigmatical pediatric disease are still poorly understood. PURPOSE: This study aims to investigate whether polymorphisms of the CD40 ligand (CD40L) gene are associated with KD and the development of coronary artery lesions (CAL) in the Taiwanese children. MATERIALS AND
methodsThe CD40L -3459 A/G and IVS4+121 A/G single nucleotide polymorphisms (SNPs) were genotyped in 167 children with KD and 1,010 ethnically matched healthy controls by TaqMan assay.
resultsNone of the CD40L polymorphisms was associated with susceptibility or CAL development of KD, and this finding was supported by the haplotype analysis.
conclusionIn summary, these results provide little support for specific CD40L SNPs in the susceptibility or CAL development of KD in Taiwanese children. However, it will be necessary to validate or replicate this association in other independent large-size ethnic groups.
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