ArticleJournal of clinical immunology2008
The dynamics of articular leukocyte trafficking and the immune response to self heat-shock protein 65 influence arthritis susceptibility.
Article in Journal of clinical immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Ras Signaling Inhibitors Attenuate Disease in Adjuvant-Induced ArthritisFrontiers in immunology · 2017Article
- Comparative antigen-induced gene expression profiles unveil novel aspects of susceptibility/resistance to adjuvant arthritis in rats.Molecular immunology · 2013Article
- Temporal cytokine expression and the target organ attributes unravel novel aspects of autoimmune arthritis.The Indian journal of medical research · 2013Review
- Immunomodulation of Autoimmune Arthritis by Herbal CAM.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Suppression of ongoing experimental arthritis by a chinese herbal formula (huo-luo-xiao-ling dan) involves changes in antigen-induced immunological and biochemical mediators of inflammation.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- The determinants of susceptibility/resistance to adjuvant arthritis in rats.Arthritis research & therapy · 2009Review
- Regulation of autoimmune arthritis by self-heat-shock proteins.Trends in immunology · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
introductionAdjuvant arthritis (AA) shares several features with human rheumatoid arthritis, and it can be induced in the Lewis (LEW) rat but not the Wistar Kyoto (WKY) rat (both RT.1(l)) by immunization with heat-killed Mycobacterium tuberculosis (Mtb). We set out to unravel the mechanisms underlying the differential susceptibility to AA of these MHC-compatible rat strains. MATERIALS AND
methodsWe compared the levels of T-cell proliferative and cytokine response to the immunoregulatory self (rat) hsp65 (Rhsp65) after an arthritogenic (Mtb) challenge and the kinetics of migration of adoptively transferred, (111)Indium-labeled, Mtb-primed leukocytes into the hind paw joints of recipient rats. RESULTS AND DISCUSSION: The WKY rats raised a significantly higher level of T-cell proliferative response coupled with a temporally opposite cytokine profile against the disease-regulating Rhsp65 compared to that of LEW rats. Moreover, the arthritogenic leukocytes accumulated into the joints of WKY rats at significantly lower numbers than that in LEW rats.
conclusionsThese results offer novel insights into the immune events influencing the pathogenesis of autoimmune arthritis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.