ArticlePlanta2008
Expression and evolutionary features of the hexokinase gene family in Arabidopsis.
Article in Planta, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed, 136 citations in OpenAlex.
- Responses of Male and Female Cucumber Flowers toPlants (Basel, Switzerland) · 2026Article
- Functional Characterization ofPlants (Basel, Switzerland) · 2026Article
- Loss of the plastidial hexokinase CsHXK3 triggers metabolic starvation and ROS imbalance leading to pollen abortion in cucumber.The Plant journal : for cell and molecular biology · 2026Article
- Hexokinase 1 facilitates post-germinative seedling growth through its catalytic function.The Plant journal : for cell and molecular biology · 2026Article
- Genome-wide identification of HXK gene families in cucumber and watermelon: CsHXK1 and ClHXK6 play key roles in responding to multiple stresses.BMC plant biology · 2026Article
- Grain under pressure: Harnessing biochemical pathways to beat drought and heat in wheat.The Plant journal : for cell and molecular biology · 2025Review
- Genomic Analysis of Hexokinase Genes in Foxtail Millet (International journal of molecular sciences · 2025Article
- Genome-Wide Identification and Expression Analysis of Hexokinase Gene Family Under Abiotic Stress in Tomato.Plants (Basel, Switzerland) · 2025Article
- Identification ofInternational journal of molecular sciences · 2025Article
- Isolation, structure analysis and expression characterization of the Hexokinase gene family in3 Biotech · 2025Article
- Transcriptome and selected metabolite analyses reveal points of sugar metabolism in the developing leaves of kiwifruit.Frontiers in plant science · 2025Article
- Bioinformatic insights into sugar signaling pathways in sugarcane growth.Scientific reports · 2024Article
- Identification of key gene networks controlling organic acid and sugar metabolism during star fruit (Averrhoa carambola) development.BMC plant biology · 2024Article
- GmHXK2 promotes the salt tolerance of soybean seedlings by mediating AsA synthesis, and auxin synthesis and distribution.BMC plant biology · 2024Article
- Article
- Structure and Expression Analysis ofInternational journal of molecular sciences · 2023Article
- Genome-Wide Characterization of Soybean Hexokinase Genes Reveals a Positive Role ofPlants (Basel, Switzerland) · 2023Article
- Identification and Expression Analysis of Hexokinases Family inPlants (Basel, Switzerland) · 2023Article
- Characterization of hexokinase gene family members inFrontiers in genetics · 2023Article
- Hexokinase1: A glucose sensor involved in drought stress response and sugar metabolism depending on its kinase activity in strawberry.Frontiers in plant science · 2023Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Arabidopsis hexokinase1 (HXK1) is a moonlighting protein that has separable functions in glucose signaling and in glucose metabolism. In this study, we have characterized expression features and glucose phosphorylation activities of the six HXK gene family members in Arabidopsis thaliana. Three of the genes encode catalytically active proteins, including a stromal-localized HXK3 protein that is expressed mostly in sink organs. We also show that three of the genes encode hexokinase-like (HKL) proteins, which are about 50% identical to AtHXK1, but do not phosphorylate glucose or fructose. Expression studies indicate that both HKL1 and HKL2 transcripts occur in most, if not all, plant tissues and that both proteins are targeted within cells to mitochondria. The HKL1 and HKL2 proteins have 6-10 amino acid insertions/deletions (indels) at the adenosine binding domain. In contrast, HKL3 transcript was detected only in flowers, the protein lacks the noted indels, and the protein has many other amino acid changes that might compromise its ability even to bind glucose or ATP. Activity measurements of HXKs modified by site-directed mutagenesis suggest that the lack of catalytic activities in the HKL proteins might be attributed to any of numerous existing changes. Sliding windows analyses of coding sequences in A. thaliana and A. lyrata ssp. lyrata revealed a differential accumulation of nonsynonymous changes within exon 8 of both HKL1 and HXK3 orthologs. We further discuss the possibility that the non-catalytic HKL proteins have regulatory functions instead of catalytic functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.