ArticlePsychopharmacology2008
A novel procedure for assessing the effects of drugs on satiation in baboons: effects of memantine and dexfenfluramine.
Article in Psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Effects of the 5-HT2C receptor agonist meta-chlorophenylpiperazine on appetite, food intake and emotional processing in healthy volunteers.Psychopharmacology · 2014Trial
- Molecular Mechanisms Against Successful Weight Loss and Promising Treatment Options in Obesity.Biomedicines · 2025Review
- Dopamine, activation of ingestion and evaluation of response efficacy: a focus on the within-session time-course of licking burst number.Psychopharmacology · 2024Review
- Article
- Memantine effects on ingestion microstructure and the effect of administration time: A within-subject study.PloS one · 2020Article
- Daily memantine treatment blunts hedonic response to sucrose in rats.Psychopharmacology · 2020Article
- Long-Term NMDAR Antagonism Correlates Weight Loss With Less Eating.Frontiers in psychiatry · 2019Article
- Sex differences in the anorexigenic effects of dexfenfluramine and amphetamine in baboons.Experimental and clinical psychopharmacology · 2018Article
- Can We Selectively Reduce Appetite for Energy-Dense Foods? An Overview of Pharmacological Strategies for Modification of Food Preference Behavior.Current neuropharmacology · 2016Review
- The uncompetitive N-methyl-D-aspartate antagonist memantine reduces binge-like eating, food-seeking behavior, and compulsive eating: role of the nucleus accumbens shell.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- The uncompetitive NMDA receptor antagonists ketamine and memantine preferentially increase the choice for a small, immediate reward in low-impulsive rats.Psychopharmacology · 2013Article
- Consumption of palatable food decreases the anorectic effects of serotonergic, but not dopaminergic drugs in baboons.Physiology & behavior · 2011Article
- Memantine reduces consumption of highly palatable food in a rat model of binge eating.Amino acids · 2011Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
rationaleProcedures for studying the effects of medications on satiation will assist the development of obesity medications.
objectivesDevelop a procedure for measuring satiation during consumption of bland and highly palatable food and determine the effect of acute intramuscular administration of dexfenfluramine (DFEN), which increases serotonin levels, and memantine (MEM), which blocks N-methyl-D: -aspartate receptors. MATERIALS AND
methodsA modified progressive ratio (PR) procedure was used to track changes in reinforcing strength when a food was consumed. The response requirement increased after each reinforcement, and reinforcing strength was estimated using the breakpoint (BP), which was the last completed response cost. There was one preferred food (sweet candy) and one chow pellet PR session per week. During each session, four male and four female adult baboons experienced three 1-h PR trials, separated by 30 min. Chow pellets were available at all other times. We examined the BP for one to 20 candies or chow pellets. Drug effects were examined when baboons had access to one and ten candies or chow pellets.
resultsBPs for candy were greater than for pellets. Varying the pellet/candy pieces per delivery produced an inverted U-shaped function on the first trial, i.e., maximal BP was observed for three items, and the BP for multiple items, but not a single item, decreased across trials, i.e., BP decreased with food intake and satiation. DFEN and MEM decreased responding with the greatest effects at ten deliveries, suggesting that DFEN and MEM enhanced satiation.
conclusionDrugs that enhance satiation for several types of food may be particularly effective for decreasing food intake.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.