ArticleThe EMBO journal2008
Yeast Rap1 contributes to genomic integrity by activating DNA damage repair genes.
Article in The EMBO journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- DecodingbioRxiv : the preprint server for biology · 2025Article
- Article
- IUPred3: prediction of protein disorder enhanced with unambiguous experimental annotation and visualization of evolutionary conservation.Nucleic acids research · 2021Article
- Article
- Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy.Nature communications · 2019Article
- Review
- Telomere shortening triggers a feedback loop to enhance end protection.Nucleic acids research · 2017Article
- Identification of a transcriptional activation domain in yeast repressor activator protein 1 (Rap1) using an altered DNA-binding specificity variant.The Journal of biological chemistry · 2017Article
- The Intra-S Checkpoint Responses to DNA Damage.Genes · 2017Review
- SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells.Genome research · 2016Article
- A highly conserved region within H2B is important for FACT to act on nucleosomes.Molecular and cellular biology · 2014Article
- Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence.Genes & development · 2013Article
- Single-cell analysis of ribonucleotide reductase transcriptional and translational response to DNA damage.Molecular and cellular biology · 2013Article
- Sen1p contributes to genomic integrity by regulating expression of ribonucleotide reductase 1 (RNR1) in Saccharomyces cerevisiae.PloS one · 2013Article
- The multifunctional Ccr4-Not complex directly promotes transcription elongation.Genes & development · 2011Article
- A novel mechanism of antagonism between ATP-dependent chromatin remodeling complexes regulates RNR3 expression.Molecular and cellular biology · 2009Article
- Dissection of coactivator requirement at RNR3 reveals unexpected contributions from TFIID and SAGA.The Journal of biological chemistry · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Rap1 (repressor-activator protein 1) is a multifunctional protein that controls telomere function, silencing and the activation of glycolytic and ribosomal protein genes. We have identified a novel function for Rap1, regulating the ribonucleotide reductase (RNR) genes that are required for DNA repair and telomere expansion. Both the C terminus and DNA-binding domain of Rap1 are required for the activation of the RNR genes, and the phenotypes of different Rap1 mutants suggest that it utilizes both regions to carry out distinct steps in the activation process. Recruitment of Rap1 to the RNR3 gene is dependent on activation of the DNA damage checkpoint and chromatin remodelling by SWI/SNF. The dependence on SWI/SNF for binding suggests that Rap1 acts after remodelling to prevent the repositioning of nucleosomes back to the repressed state. Furthermore, the recruitment of Rap1 requires TAF(II)s, suggesting a role for TFIID in stabilizing activator binding in vivo. We propose that Rap1 acts as a rheostat controlling nucleotide pools in response to shortened telomeres and DNA damage, providing a mechanism for fine-tuning the RNR genes during checkpoint activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.