ArticleJournal of virology2008
Genetic analysis of the capsid gene of genotype GII.2 noroviruses.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Norovirus vaccine against experimental human Norwalk Virus illness.The New England journal of medicine · 2011Trial
- Molecular Characterization of Noroviruses Causing Acute Gastroenteritis Outbreaks among US Military Recruits, 2013-2023.Emerging infectious diseases · 2024Article
- Influence of herd immunity on norovirus: a long-term field study of repeated viral gastroenteritis outbreaks at the same facilities.BMC infectious diseases · 2023Article
- Clinical significance and intestinal microbiota composition in immunocompromised children with norovirus gastroenteritis.PloS one · 2022Article
- Article
- Human norovirus transmission and evolution in a changing world.Nature reviews. Microbiology · 2016Review
- Molecular epidemiology of norovirus from patients with acute gastroenteritis in northwestern Spain.Epidemiology and infection · 2015Article
- Norovirus.Clinical microbiology reviews · 2015Review
- Epidemiology of human noroviruses and updates on vaccine development.Current opinion in gastroenterology · 2014Review
- Characterization of blockade antibody responses in GII.2.1976 Snow Mountain virus-infected subjects.Journal of virology · 2014Article
- Novel norovirus recombinants and of GII.4 sub-lineages associated with outbreaks between 2006 and 2010 in Belgium.Virology journal · 2011Article
- Using molecular epidemiology to trace transmission of nosocomial norovirus infection.Journal of clinical microbiology · 2011Article
- Viral shape-shifting: norovirus evasion of the human immune system.Nature reviews. Microbiology · 2010Review
- Heterotypic humoral and cellular immune responses following Norwalk virus infection.Journal of virology · 2010Article
- Noroviruses - State of the Art.Food and environmental virology · 2010Article
- Molecular epidemiology of genogroup II-genotype 4 noroviruses in the United States between 1994 and 2006.Journal of clinical microbiology · 2010Article
- Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noroviruses (NoVs) are considered to be a major cause of acute nonbacterial gastroenteritis in humans. The NoV genus is genetically diverse, and genotype GII.4 has been most commonly identified worldwide in recent years. In this study we analyzed the complete capsid gene of NoV strains belonging to the less prevalent genotype GII.2. We compared a total of 36 complete capsid sequences of GII.2 sequences obtained from the GenBank (n = 5) and from outbreaks or sporadic cases that occurred in The Netherlands (n = 10) and in Osaka City, Japan (n = 21), between 1976 and 2005. Alignment of all capsid sequences did not show fixation of amino acid substitutions over time as an indication for genetic drift. In contrast, when strains previously recognized as recombinants were excluded from the alignment, genetic drift was observed. Substitutions were found at five informative sites (two in the P1 subdomain and three in the P2 subdomain), segregating strains into five genetic groups (1994 to 1997, 1999 to 2000, 2001 to 2003, 2004, and 2005). Only one amino acid position changed consistently between each group (position 345). Homology modeling of the GII.2 capsid protein showed that the five amino acids were located on the surface of the capsid and close to each other at the interface of two monomers. The data suggest that these changes were induced by selective pressure, driving virus evolution. Remarkably, this was observed only for nonrecombinant genomes, suggesting differences in behavior with recombinant strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.