ArticleJournal of the American Society of Nephrology : JASN2008
Irradiation prolongs survival of Alport mice.
Article in Journal of the American Society of Nephrology : JASN, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Clinical practice recommendations for the treatment of Alport syndrome: a statement of the Alport Syndrome Research Collaborative.Pediatric nephrology (Berlin, Germany) · 2013Guideline
- The Protective Role of KANK1 in Podocyte Injury.International journal of molecular sciences · 2024Article
- Cell and gene therapy for kidney disease.Nature reviews. Nephrology · 2023Review
- Podocyte-specific Crb2 knockout mice develop focal segmental glomerulosclerosis.Scientific reports · 2021Article
- COL4A6 is dispensable for autosomal recessive Alport syndrome.Scientific reports · 2016Article
- Searching for a treatment for Alport syndrome using mouse models.World journal of nephrology · 2014Review
- Alport syndrome: its effects on the glomerular filtration barrier and implications for future treatment.The Journal of physiology · 2014Review
- Feasibility of repairing glomerular basement membrane defects in Alport syndrome.Journal of the American Society of Nephrology : JASN · 2014Article
- An update on the pathomechanisms and future therapies of Alport syndrome.Pediatric nephrology (Berlin, Germany) · 2013Review
- Alport syndrome--insights from basic and clinical research.Nature reviews. Nephrology · 2013Review
- Glomerular pathology in Alport syndrome: a molecular perspective.Pediatric nephrology (Berlin, Germany) · 2012Review
- Injection of amniotic fluid stem cells delays progression of renal fibrosis.Journal of the American Society of Nephrology : JASN · 2012Article
- Stem cells as a therapeutic approach to chronic kidney diseases.Current urology reports · 2012Review
- Kidney repair and stem cells: a complex and controversial process.Pediatric nephrology (Berlin, Germany) · 2011Review
- Mesenchymal stem cells as a therapeutic approach to glomerular diseases: benefits and risks.Kidney international supplements · 2011Review
- Glomerular diseases: genetic causes and future therapeutics.Nature reviews. Nephrology · 2010Review
- Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome.The Journal of clinical investigation · 2010Article
- Stem cell therapies benefit Alport syndrome.Journal of the American Society of Nephrology : JASN · 2009Article
- Cellular origins of type IV collagen networks in developing glomeruli.Journal of the American Society of Nephrology : JASN · 2009Article
- Stem cell therapy for Alport syndrome: the hope beyond the hype.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2009Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alport syndrome is a hereditary nephropathy that results in irreversible, progressive renal failure. Recent reports suggested that bone marrow transplantation (BMT) has a beneficial, short-term effect on renal injury in Alport (Col4a3(-/-)) mice, but its long-term effects, especially with regard to survival, are unknown. In this study, Alport mice received a transplant of either wild-type or Col4a3(-/-) bone marrow cells. Surprising, laboratory evaluations and renal histology demonstrated similar findings in both transplanted groups. Transplanted cells accounted for >10% of glomerular cells at 8 wk, but type IV collagen alpha3 chains were not detected in glomerular basement membranes of either group by immunofluorescence or Western blot analysis, although Col4a3 mRNA in the kidney could be amplified by reverse transcription-PCR in knockout mice that received a transplant of wild-type bone marrow. Both transplanted groups, however, survived approximately 1.5 times longer than untreated knockout mice (log rank P < 0.05). These data suggested that irradiation, which preceded BMT, may have conferred a survival benefit; therefore, the survival time of knockout mice was assessed after sublethal irradiation (3, 6, and 7 Gy) without subsequent BMT. A strong positive correlation between irradiation dosage and survival time was identified (P < 0.0001). In conclusion, the improved survival observed in Alport mice that received a transplant of wild-type bone marrow might be primarily attributed to as-yet-unidentified effects of irradiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.