ArticleAmerican journal of physiology. Renal physiology2008
Low salt intake increases adenosine type 1 receptor expression and function in the rat proximal tubule.
Article in American journal of physiology. Renal physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Abnormal increase in urinary aquaporin-2 excretion in response to hypertonic saline in essential hypertension.BMC nephrology · 2012Trial
- Proximal Tubule CD73 Is Critical in Renal Ischemia-Reperfusion Injury Protection.Journal of the American Society of Nephrology : JASN · 2017Article
- Caffeine-induced diuresis and natriuresis is independent of renal tubular NHE3.American journal of physiology. Renal physiology · 2015Article
- Adenosine, type 1 receptors: role in proximal tubule Na+ reabsorption.Acta physiologica (Oxford, England) · 2015Review
- Purinergic signalling in the kidney in health and disease.Purinergic signalling · 2014Review
- Adenosine inhibits renin release from juxtaglomerular cells via an A1 receptor-TRPC-mediated pathway.American journal of physiology. Renal physiology · 2013Article
- Adenosine A1-receptor knockout mice have a decreased blood pressure response to low-dose ANG II infusion.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Acute saline expansion increases nephron filtration and distal flow rate but maintains tubuloglomerular feedback responsiveness: role of adenosine A(1) receptors.American journal of physiology. Renal physiology · 2012Article
- Glomerular tubular balance is suppressed in adenosine type 1 receptor-deficient mice.American journal of physiology. Renal physiology · 2010Article
- Renal proximal tubular reabsorption is reduced in adult spontaneously hypertensive rats: roles of superoxide and Na+/H+ exchanger 3.Hypertension (Dallas, Tex. : 1979) · 2009Article
- Enhanced tubuloglomerular feedback in mice with vascular overexpression of A1 adenosine receptors.American journal of physiology. Renal physiology · 2009Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
Adenosine mediates Na+ reabsorption in the proximal tubule (PT) and other segments by activating adenosine type 1 receptors (A1-AR). We tested the hypothesis that A1-AR in the PT is regulated by salt intake and participates in the kidney adaptation to changes in salt intake. Absolute fluid reabsorption (Jv) was measured by direct in vivo microperfusion and recollection in rats maintained on low (LS; 0.03% Na, wt/wt)-, normal (NS; 0.3% Na)-, and high-salt (HS; 3.0% Na) diets for 1 wk. The effect of microperfusion of BG9719 a highly selective inhibitor of A1-ARs or adenosine deaminase (AD), which metabolizes adenosine, was measured in each group. Jv was higher in PT from LS rats (LA: 2.8 +/- 0.2 vs. NS: 2.1 +/- 0.2 nl.min(-1).mm(-1), P < 0.001). Jv in HS rats was not different from NS. BG9719 reduced Jv in LS rats by 66 +/- 6% (LS: 2.8 +/- 0.2 vs LS+CVT: 1.3 +/- 0.3 nl.min(-1).mm(-1), P < 0.001), which was greater than its effect in NS (45 +/- 4%) or HS (41 +/- 4%) rats. AD reduced Jv similarly, suggesting that A1-ARs are activated by local production of adenosine. Expression of A1-AR mRNA and protein was higher (P < 0.01) in microdissected PTs in LS rats compared with NS and HS. We conclude that A1-ARs in the PT are increased by low salt intake and that A1-AR participates in the increased PT reabsorption of solute and fluid in response to low salt intake.
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