SynthesisBMJ (Clinical research ed.)2008
Accuracy of mean arterial pressure and blood pressure measurements in predicting pre-eclampsia: systematic review and meta-analysis.
Synthesis in BMJ (Clinical research ed.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 4 syntheses or guidelines pooled it, 239 citations in OpenAlex.
- Replacing salt with low-sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women.The Cochrane database of systematic reviews · 2022Pooled it
- The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019Guideline
- Chronic hypertension and pregnancy outcomes: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2014Pooled it
- Diagnosing suspected scaphoid fractures: a systematic review and meta-analysis.Clinical orthopaedics and related research · 2010Pooled it
- Diet quality and blood pressure among pregnant women with overweight or obesity: A secondary analysis of two randomized controlled trials.Acta obstetricia et gynecologica Scandinavica · 2024Trial
- The association between sleep-disordered breathing and maternal endothelial and metabolic markers in pregnancies complicated by obesity.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Trial
- Clinical risk prediction for pre-eclampsia in nulliparous women: development of model in international prospective cohort.BMJ (Clinical research ed.) · 2011Trial
- Article
- Association Between Gestational Blood Pressure Trajectories and Postpartum Normotension Recovery in Hypertensive Disorders: Retrospective Cohort Study.JMIR public health and surveillance · 2026Article
- Article
- The Role of Mid-Trimester BUN and Creatinine Assessment in Predicting Preeclampsia: Retrospective Case-Control Study.Medicina (Kaunas, Lithuania) · 2025Article
- Incorporation of Mean Arterial Pressure in Clinical Practice Using Quality Improvement Initiative.Journal of obstetrics and gynaecology of India · 2025Article
- Mean arterial pressure at the first prenatal visit as an early predictor of preeclampsia.Pregnancy (Hoboken, N.J.) · 2025Article
- Impaired SREBP1-mediated regulation of lipid metabolism promotes inflammation in chronic endometritis.Frontiers in immunology · 2025Article
- Evaluation of Risk Factor Screening Using the Ministry of Health's Scoring System for the Incidence of Early-Onset Preeclampsia in Primary Health Service.International journal of women's health · 2025Article
- Arterial stiffness as a novel tool for the early prediction of preeclampsia: a perspective.Journal of human hypertension · 2024Review
- Associations of fasting plasma glucose and glycosylated hemoglobin levels at less than 24 weeks of gestation with hypertensive disorders of pregnancy: the BOSHI study.Endocrine journal · 2024Article
- First Trimester Preeclampsia Screening and Prevention: Perspective in Chinese Mainland.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2024Article
- Predictors of Preeclampsia in the First Trimester in Normotensive and Chronic Hypertensive Pregnant Women.Journal of clinical medicine · 2023Article
- Association of mean arterial pressure with non-alcoholic fatty liver disease: results from the NAGALA study.Frontiers in cardiovascular medicine · 2023Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the accuracy of using systolic and diastolic blood pressure, mean arterial pressure, and increase of blood pressure to predict pre-eclampsia.
designSystematic review with meta-analysis of data on test accuracy. DATA SOURCES: Medline, Embase, Cochrane Library, Medion, checking reference lists of included articles and reviews, contact with authors. Review methods Without language restrictions, two reviewers independently selected the articles in which the accuracy of blood pressure measurement during pregnancy was evaluated to predict pre-eclampsia. Data were extracted on study characteristics, quality, and results to construct 2x2 tables. Summary receiver operating characteristic curves and likelihood ratios were generated for the various levels and their thresholds.
results34 studies, testing 60 599 women (3341 cases of pre-eclampsia), were included. In women at low risk for pre-eclampsia, the areas under the summary receiver operating characteristic curves for blood pressure measurement in the second trimester were 0.68 (95% confidence interval 0.64 to 0.72) for systolic blood pressure, 0.66 (0.59 to 0.72) for diastolic blood pressure, and 0.76 (0.70 to 0.82) for mean arterial pressure. Findings for the first trimester showed a similar pattern. Second trimester mean arterial pressure of 90 mm Hg or more showed a positive likelihood ratio of 3.5 (95% confidence interval 2.0 to 5.0) and a negative likelihood ratio of 0.46 (0.16 to 0.75). In women deemed to be at high risk, a diastolic blood pressure of 75 mm Hg or more at 13 to 20 weeks' gestation best predicted pre-eclampsia: positive likelihood ratio 2.8 (1.8 to 3.6), negative likelihood ratio 0.39 (0.18 to 0.71). Additional subgroup analyses did not show improved predictive accuracy.
conclusionWhen blood pressure is measured in the first or second trimester of pregnancy, the mean arterial pressure is a better predictor for pre-eclampsia than systolic blood pressure, diastolic blood pressure, or an increase of blood pressure.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.