SynthesisBMJ (Clinical research ed.)2008
Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger adults: meta-analysis of randomised trials.
Synthesis in BMJ (Clinical research ed.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 245 papers, 22 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
245 citing papers in PubMed, 22 syntheses or guidelines pooled it.
- Identifying optimal primary prevention interventions for major cardiovascular disease events and all-cause mortality: a systematic review and hierarchical network meta-analysis of RCTs.Health technology assessment (Winchester, England) · 2025 · on this mapPooled it
- Disparities in Cardiovascular Disease-Related Outcomes Among Cancer Survivors in the United States: A Systematic Review of the Literature.Heart, lung & circulation · 2024Pooled it
- Evening versus morning dosing regimen drug therapy for hypertension.The Cochrane database of systematic reviews · 2024Pooled it
- Disentangling the varying associations between systolic blood pressure and health outcomes in the very old: an individual patient data meta-analysis.Journal of hypertension · 2022Pooled it
- How Much Lowering of Blood Pressure Is Required to Prevent Cardiovascular Disease in Patients With and Without Previous Cardiovascular Disease?Current cardiology reports · 2022Pooled it
- Pooled it
- Interventions for reducing sedentary behaviour in people with stroke.The Cochrane database of systematic reviews · 2021Pooled it
- Walking for hypertension.The Cochrane database of systematic reviews · 2021Pooled it
- Pooled it
- The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019Guideline
- Effect Modification by Age on the Benefit or Harm of Antihypertensive Treatment for Elderly Hypertensives: A Systematic Review and Meta-analysis.American journal of hypertension · 2019Pooled it
- Cost-effectiveness of interventions to control cardiovascular diseases and diabetes mellitus in South Asia: a systematic review.BMJ open · 2018Pooled it
- Effectiveness and safety of beta blockers in the management of hypertension in older adults: a systematic review to help reduce inappropriate prescribing.BMC geriatrics · 2017Pooled it
- Pharmacotherapy for hypertension in adults aged 18 to 59 years.The Cochrane database of systematic reviews · 2017Pooled it
- 7th Brazilian Guideline of Arterial Hypertension: Chapter 11 - Arterial Hypertension in the elderlyArquivos brasileiros de cardiologia · 2016Guideline
- Guideline
- Hypertension in Older Persons: A Systematic Review of National and International Treatment Guidelines.Journal of clinical hypertension (Greenwich, Conn.) · 2015Pooled it
- Diabetes and hypertension prevalence in homeless adults in the United States: a systematic review and meta-analysis.American journal of public health · 2015Pooled it
- Pharmacotherapy for hypertension in older adults: a systematic review.Drugs & aging · 2014Pooled it
- Amlodipine and cardiovascular outcomes in hypertensive patients: meta-analysis comparing amlodipine-based versus other antihypertensive therapy.The Korean journal of internal medicine · 2014Pooled it
185 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo quantify the relative risk reductions achieved with different regimens to lower blood pressure in younger and older adults.
designMeta-analyses and meta-regression analyses used to compare the effects on the primary outcome between two age groups (<65 v > or =65 years). Evidence for an interaction between age and the effects of treatment sought by fitting age as a continuous variable and estimating overall effects across trials.
main outcome measuresPRIMARY OUTCOME: total major cardiovascular events.
results31 trials, with 190 606 participants, were included. The meta-analyses showed no clear difference between age groups in the effects of lowering blood pressure or any difference between the effects of the drug classes on major cardiovascular events (all P> or =0.24). Neither was there any significant interaction between age and treatment when age was fitted as a continuous variable (all P>0.09). The meta-regressions also showed no difference in effects between the two age groups for the outcome of major cardiovascular events (<65 v > or =65; P=0.38).
conclusionsReduction of blood pressure produces benefits in younger (<65 years) and older (> or =65 years) adults, with no strong evidence that protection against major vascular events afforded by different drug classes varies substantially with age.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.