ArticleMolecular biology and evolution2008
Overdispersion of the molecular clock: temporal variation of gene-specific substitution rates in Drosophila.
Article in Molecular biology and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Epistasis plays a limited role in driving entrenchment during neutral protein evolution.Genome biology · 2026Article
- ClockstaRX: Testing Molecular Clock Hypotheses With Genomic Data.Genome biology and evolution · 2024Article
- Learning Retention Mechanisms and Evolutionary Parameters of Duplicate Genes from Their Expression Data.Molecular biology and evolution · 2021Article
- Epistatic contributions promote the unification of incompatible models of neutral molecular evolution.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Neutral Theory in Light of Natural Selection.Molecular biology and evolution · 2018Article
- Genetic Adaptation of Schizothoracine Fish to the Phased Uplifting of the Qinghai-Tibetan Plateau.G3 (Bethesda, Md.) · 2017Article
- Clonal evolution of glioblastoma under therapy.Nature genetics · 2016Article
- What does it take to evolve an enhancer? A simulation-based study of factors influencing the emergence of combinatorial regulation.Genome biology and evolution · 2015Article
- Universal distribution of mutational effects on protein stability, uncoupling of protein robustness from sequence evolution and distinct evolutionary modes of prokaryotic and eukaryotic proteins.Physical biology · 2015Article
- Evolution on neutral networks accelerates the ticking rate of the molecular clock.Journal of the Royal Society, Interface · 2015Article
- Uncovering adaptive evolution in the human lineage.BMC genomics · 2014Article
- Scombroid fishes provide novel insights into the trait/rate associations of molecular evolution.Journal of molecular evolution · 2014Article
- Universal pacemaker of genome evolution in animals and fungi and variation of evolutionary rates in diverse organisms.Genome biology and evolution · 2014Article
- Stability along with extreme variability in core genome evolution.Genome biology and evolution · 2013Article
- Why does a protein's evolutionary rate vary over time?Genome biology and evolution · 2013Article
- Universal pacemaker of genome evolution.PLoS computational biology · 2012Article
- On the diversity of malaria parasites in African apes and the origin of Plasmodium falciparum from Bonobos.PLoS pathogens · 2010Article
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Abstract
Simple models of molecular evolution assume that sequences evolve by a Poisson process in which nucleotide or amino acid substitutions occur as rare independent events. In these models, the expected ratio of the variance to the mean of substitution counts equals 1, and substitution processes with a ratio greater than 1 are called overdispersed. Comparing the genomes of 10 closely related species of Drosophila, we extend earlier evidence for overdispersion in amino acid replacements as well as in four-fold synonymous substitutions. The observed deviation from the Poisson expectation can be described as a linear function of the rate at which substitutions occur on a phylogeny, which implies that deviations from the Poisson expectation arise from gene-specific temporal variation in substitution rates. Amino acid sequences show greater temporal variation in substitution rates than do four-fold synonymous sequences. Our findings provide a general phenomenological framework for understanding overdispersion in the molecular clock. Also, the presence of substantial variation in gene-specific substitution rates has broad implications for work in phylogeny reconstruction and evolutionary rate estimation.
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