ArticleBiology direct2008
U12 intron positions are more strongly conserved between animals and plants than U2 intron positions.
Article in Biology direct, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Where the minor things are: a pan-eukaryotic survey suggests neutral processes may explain much of minor intron evolution.Nucleic acids research · 2023Article
- Dysregulated minor intron splicing in cancer.Cancer science · 2022Review
- Temporal regulation of alternative splicing events in rice memory under drought stress.Plant diversity · 2022Article
- Inhibition of minor intron splicing reduces Na+ and Ca2+ channel expression and function in cardiomyocytes.Journal of cell science · 2022Article
- Minor Intron Splicing from Basic Science to Disease.International journal of molecular sciences · 2021Review
- Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila.Nature communications · 2020Article
- Loss of U11 small nuclear RNA in the developing mouse limb results in micromelia.Development (Cambridge, England) · 2020Article
- Differential isoform expression and alternative splicing in sex determination in mice.BMC genomics · 2019Article
- An Integrated Model of Minor Intron Emergence and Conservation.Frontiers in genetics · 2019Article
- The emerging role of minor intron splicing in neurological disorders.Cell stress · 2018Review
- A Role of U12 Intron in Proper Pre-mRNA Splicing of PlantFrontiers in plant science · 2018Article
- Intron evolution in Neurospora: the role of mutational bias and selection.Genome research · 2015Article
- Origin of spliceosomal introns and alternative splicing.Cold Spring Harbor perspectives in biology · 2014Article
- Article
- Complexity of the alternative splicing landscape in plants.The Plant cell · 2013Review
- Minor introns are embedded molecular switches regulated by highly unstable U6atac snRNA.eLife · 2013Article
- Origin and evolution of spliceosomal introns.Biology direct · 2012Review
- U12-type spliceosomal introns of Insecta.International journal of biological sciences · 2012Article
- Gene expression profiling of U12-type spliceosome mutant Drosophila reveals widespread changes in metabolic pathways.PloS one · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We report that the positions of minor, U12 introns are conserved in orthologous genes from human and Arabidopsis to an even greater extent than the positions of the major, U2 introns. The U12 introns, especially, conserved ones are concentrated in 5'-portions of plant and animal genes, where the U12 to U2 conversions occurs preferentially in the 3'-portions of genes. These results are compatible with the hypothesis that the high level of conservation of U12 intron positions and their persistence in genomes despite the unidirectional U12 to U2 conversion are explained by the role of the slowly excised U12 introns in down-regulation of gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.