ArticleThe protein journal2008
Amino acid biases in the N- and C-termini of proteins are evolutionarily conserved and are conserved between functionally related proteins.
Article in The protein journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- The Influence of Codon Usage, Protein Abundance, and Protein Stability on Protein Evolution Vary by Evolutionary Distance and the Type of Protein.The protein journal · 2022Article
- Impact of C-terminal amino acid composition on protein expression in bacteria.Molecular systems biology · 2020Article
- REPARATION: ribosome profiling assisted (re-)annotation of bacterial genomes.Nucleic acids research · 2017Article
- Classification of bacteria based on the biases of terminal amino acid residues.The protein journal · 2011Article
- Profiling of N-acetylated protein termini provides in-depth insights into the N-terminal nature of the proteome.Molecular & cellular proteomics : MCP · 2010Article
- Prediction of catalytic residues using the variation of stereochemical properties.The protein journal · 2009Article
- Using genome-wide protein sequence data to predict amino acid conservation.The protein journal · 2008Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
Analysis of the Arabidopsis thaliana, Saccharomyces cerevisiae, Mus musculus, Escherichia coli, Bacillus subtilis, Thermoplasma acidophilum, and Sulfolobus tokodaii genomes demonstrate that many amino acid biases occur at the N- and C-termini of proteins, a statistically significant number of these biases are evolutionarily conserved, and these biases occur in amino acids beyond the first and last five amino acids. Analyses designed to shed light on the mechanism causing amino acid biases suggest that in at least some cases the bias is caused by forces acting at the nucleic acid level. It is also demonstrated that in E. coli functionally related proteins show similar biases at the N- and C-termini suggesting that the mechanisms causing the biases are complex and in some cases are related to function.
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Registered trials
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