ArticleInternational journal of legal medicine2008
Analysis of mitochondrial length heteroplasmy in monozygous and non-monozygous siblings.
Article in International journal of legal medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Multiplexed Microsphere Suspension-Array Assay for Urine Mitochondrial DNA Typing by C-Stretch Length in Hypervariable Regions.Journal of clinical medicine research · 2018Article
- Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity.Nucleic acids research · 2016Article
- Length heteroplasmy of the polyC-polyT-polyC stretch in the dog mtDNA control region.International journal of legal medicine · 2015Article
- Mitochondrial DNA heteroplasmy in diabetes and normal adults: role of acquired and inherited mutational patterns in twins.Human molecular genetics · 2012Article
- Evaluating sequence-derived mtDNA length heteroplasmy by amplicon size analysis.Forensic science international. Genetics · 2011Article
- Behavioral genetic approach to the study of dyslexia.Journal of developmental and behavioral pediatrics : JDBP · 2010Article
- Sequence-length variation of mtDNA HVS-I C-stretch in Chinese ethnic groups.Journal of Zhejiang University. Science. B · 2009Article
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Authors and funding
6 authors.
Funding
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Abstract
The segregation of mitochondrial genomes and the inheritance of mitochondrial DNA are constant matters of debate. To obtain more information about this issue and to answer the question whether or not it is possible to distinguish mitochondrial DNA (mtDNA) samples from monozygous individuals by analysing heteroplasmic length variants, 290 monozygous and 121 dizygous twin pairs and 34 sets of multiples were studied by RFLP and partly by direct sequencing. A factor D describing the respective pattern of length variants in a given sample was also calculated. The results show that monozygous individuals exhibit a significantly lower median and closer distribution of D than non-monozygous siblings. Thus, a differentiation of mtDNA samples from monozygous twins by this trait is not possible. The high percentage of heteroplasmic individuals, the low median of the D values and the unexpectedly very similar distribution of length variants in monozygotic individuals support the existence of a relatively wide bottleneck or the assumption of a regeneration of length heteroplasmy following a tight bottleneck and agree with a random segregation of mtDNA genomes in dividing oocytes.
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