ArticlePloS one2008
Dual targeted mitochondrial proteins are characterized by lower MTS parameters and total net charge.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 72 citations in OpenAlex.
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- An Interplay between Mitochondrial and ER Targeting of a Bacterial Signal Peptide in Plants.Plants (Basel, Switzerland) · 2023Article
- Mitochondrial genome undergoes de novo DNA methylation that protects mtDNA against oxidative damage during the peri-implantation window.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Subcellular Localization of Fad1p inLife (Basel, Switzerland) · 2021Article
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- Actin reduction by MsrB2 is a key component of the cytokinetic abscission checkpoint and prevents tetraploidy.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- PtomtAPX, a mitochondrial ascorbate peroxidase, plays an important role in maintaining the redox balance of Populus tomentosa Carr.Scientific reports · 2019Article
- UPRCell research · 2018Review
- Bacterial fumarase and L-malic acid are evolutionary ancient components of the DNA damage response.eLife · 2017Article
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- Mitochondrial BMI1 maintains bioenergetic homeostasis in cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- MitoFates: improved prediction of mitochondrial targeting sequences and their cleavage sites.Molecular & cellular proteomics : MCP · 2015Article
- A small system--high-resolution study of metabolic adaptation in the central metabolic pathway to temperate climates in Drosophila melanogaster.Molecular biology and evolution · 2014Article
- OxLDL triggers retrograde translocation of arginase2 in aortic endothelial cells via ROCK and mitochondrial processing peptidase.Circulation research · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn eukaryotic cells, identical proteins can be located in different subcellular compartments (termed dual-targeted proteins). METHODOLOGY/PRINCIPAL
findingsWe divided a reference set of mitochondrial proteins (published single gene studies) into two groups: i) Dual targeted mitochondrial proteins and ii) Exclusive mitochondrial proteins. Mitochondrial proteins were considered dual-targeted if they were also found or predicted to be localized to the cytosol, the nucleus, the endoplasmic reticulum (ER) or the peroxisome. We found that dual localized mitochondrial proteins have i) A weaker mitochondrial targeting sequence (MitoProtII score, hydrophobic moment and number of basic residues) and ii) a lower whole-protein net charge, when compared to exclusive mitochondrial proteins. We have also generated an annotation list of dual-targeted proteins within the predicted yeast mitochondrial proteome. This considerably large group of dual-localized proteins comprises approximately one quarter of the predicted mitochondrial proteome. We supported this prediction by experimental verification of a subgroup of the predicted dual targeted proteins. CONCLUSIONS/SIGNIFICANCE: Taken together, these results establish dual targeting as a widely abundant phenomenon that should affect our concepts of gene expression and protein function. Possible relationships between the MTS/mature sequence traits and protein dual targeting are discussed.
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