ArticlePloS one2008
Different region analysis for genotyping Yersinia pestis isolates from China.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- A field-deployable high-resolution SNP genotyping platform for rapid surveillance ofVirulence · 2026Article
- Emergence, global dispersal, and local adaptations ofApplied and environmental microbiology · 2026Review
- Insights into Yersinia pestis evolution through rearrangement analysis of 242 complete genomes.Nature genetics · 2025Article
- Genomic diversity and transmission patterns of Yersinia pestis in Inner Mongolia Autonomous Region, China.Communications biology · 2024Article
- Genomic epidemiological analysis of county-scale Yersinia pestis spread pattern over 50 years in a Southwest Chinese prefecture.PLoS neglected tropical diseases · 2023Article
- AncientProceedings. Biological sciences · 2023Article
- Complete mitochondrial genome ofFrontiers in veterinary science · 2023Article
- Applications of polymerase chain reaction-based methods for the diagnosis of plague (Review).Experimental and therapeutic medicine · 2022Review
- Flea index predicts plague epizootics among great gerbils (Rhombomys opimus) in the Junggar Basin China plague focus.Parasites & vectors · 2022Article
- First Case Report of Human Plague Caused by Excavation, Skinning, and Eating of a Hibernating Marmot (Frontiers in public health · 2022Article
- Genetic source tracking of human plague cases in Inner Mongolia-Beijing, 2019.PLoS neglected tropical diseases · 2021Article
- Genetic diversity and spatial-temporal distribution of Yersinia pestis in Qinghai Plateau, China.PLoS neglected tropical diseases · 2018Article
- Ten years of surveillance of the Yulong plague focus in China and the molecular typing and source tracing of the isolates.PLoS neglected tropical diseases · 2018Article
- Reemergence of human plague in Yunnan, China in 2016.PloS one · 2018Article
- Phenotypic and Molecular Genetic Characteristics ofThe American journal of tropical medicine and hygiene · 2018Article
- Redefining the differences in gene content betweenMicrobial genomics · 2015Article
- Transmission efficiency of the plague pathogen (Y. pestis) by the flea, Xenopsylla skrjabini, to mice and great gerbils.Parasites & vectors · 2015Article
- Climate-driven introduction of the Black Death and successive plague reintroductions into Europe.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Chromosomal rearrangement features of Yersinia pestis strains from natural plague foci in China.The American journal of tropical medicine and hygiene · 2014Article
- YpfΦ: a filamentous phage acquired by Yersinia pestis.Frontiers in microbiology · 2014Review
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDFR (different region) analysis has been developed for typing Yesinia pestis in our previous study, and in this study, we extended this method by using 23 DFRs to investigate 909 Chinese Y. pestis strains for validating DFR-based genotyping method and better understanding adaptive microevolution of Y. pestis. METHODOLOGY/PRINCIPAL
findingsOn the basis of PCR and Bionumerics data analysis, 909 Y. pestis strains were genotyped into 32 genomovars according to their DFR profiles. New terms, Major genomovar and Minor genomovar, were coined for illustrating evolutionary relationship between Y. pestis strains from different plague foci and different hosts. In silico DFR profiling of the completed or draft genomes shed lights on the evolutionary scenario of Y. pestis from Y. pseudotuberculosis. Notably, several sequenced Y. pestis strains share the same DFR profiles with Chinese strains, providing data for revealing the global plague foci expansion. CONCLUSIONS/SIGNIFICANCE: Distribution of Y. pestis genomovars is plague focus-specific. Microevolution of biovar Orientalis was deduced according to DFR profiles. DFR analysis turns to be an efficient and inexpensive method to portrait the genome plasticity of Y. pestis based on horizontal gene transfer (HGT). DFR analysis can also be used as a tool in comparative and evolutionary genomic research for other bacteria with similar genome plasticity.
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