ArticlePloS one2008
A transcriptional enhancer from the coding region of ADAMTS5.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- A map of cis-regulatory modules and constituent transcription factor binding sites in 80% of the mouse genome.BMC genomics · 2022Article
- Treatment of DystrophicBiomolecules · 2020Article
- Transcriptional induction of ADAMTS5 protein by nuclear factor-κB (NF-κB) family member RelA/p65 in chondrocytes during osteoarthritis development.The Journal of biological chemistry · 2013Article
- The role of MyoD1 and histone modifications in the activation of muscle enhancers.Epigenetics · 2013Article
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- DNA shape, genetic codes, and evolution.Current opinion in structural biology · 2011Review
- IP(3)-dependent, post-tetanic calcium transients induced by electrostimulation of adult skeletal muscle fibers.The Journal of general physiology · 2010Article
- Comparative genomics reveals a functional thyroid-specific element in the far upstream region of the PAX8 gene.BMC genomics · 2010Article
- Exonic remnants of whole-genome duplication reveal cis-regulatory function of coding exons.Nucleic acids research · 2010Article
- Identification of a Cis-acting regulatory polymorphism in a Eucalypt COBRA-like gene affecting cellulose content.Genetics · 2009Article
- Transcriptional coupling of synaptic transmission and energy metabolism: role of nuclear respiratory factor 1 in co-regulating neuronal nitric oxide synthase and cytochrome c oxidase genes in neurons.Biochimica et biophysica acta · 2009Article
- Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues.Gene expression patterns : GEP · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe revelation that the human genome encodes only approximately 25,000 genes and thus cannot account for phenotypic complexity has been one of the biggest surprises in the post-genomic era. However, accumulating evidence suggests that transcriptional regulation may be in large part responsible for this observed mammalian complexity. Consequently, there has been a strong drive to locate cis-regulatory regions in mammalian genomes in order to understand the unifying principles governing these regions, including their genomic distribution. Although a number of systematic approaches have been developed, these all discount coding sequence. METHODOLOGY/PRINCIPAL
findingsUsing the computational tool PRI (Pattern-defined Regulatory Islands), which does not mask coding sequence, we identified a regulatory region associated with the gene ADAMTS5 that encompasses the entirety of the essential coding exon 2. We demonstrate through a combination of chromatin immunoprecipitation and reporter gene studies that this region can not only bind the myogenic transcription factors MYOD and myogenin and the E-protein HEB but can also function as a very strong myogenic transcriptional enhancer. CONCLUSIONS/SIGNIFICANCE: Thus, we report the identification and detailed characterization of an exonic enhancer. Ultimately, this leads to the interesting question of why evolution would be so parsimonious in the functional assignment of sequence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.