Trial reportThe Journal of clinical endocrinology and metabolism2008
The effects of growth hormone and/or testosterone on whole body protein kinetics and skeletal muscle gene expression in healthy elderly men: a randomized controlled trial.
Trial report in The Journal of clinical endocrinology and metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Anabolic-steroid therapy after geriatric proximal femur fracture: a level I evidence systematic review and meta-analysis of bone density, functional recovery, and safety.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Pooled it
- Passing the anaerobic threshold is associated with substantial changes in the gene expression profile in white blood cells.European journal of applied physiology · 2012Trial
- Basal growth hormone concentration increased following a weight loss focused dietary intervention in older overweight and obese women.The journal of nutrition, health & aging · 2012Trial
- Whole-body and muscle protein metabolism are not affected by acute deviations from habitual protein intake in older men: the Hormonal Regulators of Muscle and Metabolism in Aging (HORMA) Study.The American journal of clinical nutrition · 2011Trial
- Higher muscle protein synthesis in women than men across the lifespan, and failure of androgen administration to amend age-related decrements.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Trial
- Growth hormone and aging: a clinical review.Frontiers in aging · 2025Review
- The Metabolic Syndrome, a Human Disease.International journal of molecular sciences · 2024Review
- The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health.International journal of molecular sciences · 2022Review
- Effects of blood flow restriction (BFR) with resistance exercise on musculoskeletal health in older adults: a narrative review.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2022Review
- Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications.Mayo Clinic proceedings · 2021Review
- Effect of Testosterone on FGF2, MRF4, and Myostatin in Hypogonadotropic Hypogonadism: Relevance to Muscle Growth.The Journal of clinical endocrinology and metabolism · 2019Article
- Article
- The Role of the Multiple Hormonal Dysregulation in the Onset of "Anemia of Aging": Focus on Testosterone, IGF-1, and Thyroid Hormones.International journal of endocrinology · 2015Review
- Hormone replacement therapy and physical function in healthy older men. Time to talk hormones?Endocrine reviews · 2012Review
- Sarcopenia: designing phase IIB trials.The journal of nutrition, health & aging · 2011Article
- Evaluation of early biomarkers of muscle anabolic response to testosterone.Journal of cachexia, sarcopenia and muscle · 2011Article
- Protein metabolism in women and men: similarities and disparities.Current opinion in clinical nutrition and metabolic care · 2011Review
- Hormone treatment and muscle anabolism during aging: androgens.Clinical nutrition (Edinburgh, Scotland) · 2010Review
- Validated treatments and therapeutics prospectives regarding pharmacological products for sarcopenia.The journal of nutrition, health & aging · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
contextAlterations of protein turnover may contribute to the progressive decline of muscle mass with aging.
objectiveOur objective was to examine the effects of near-physiological recombinant human GH and/or testosterone (T) administration to older men on whole body protein kinetics and muscle gene expression. DESIGN, SETTINGS, AND
participantsA 6-month randomized, double-blind, placebo-controlled trial in 21 healthy elderly men aged 65-75 yr, was performed. Participants were randomized to receive placebo GH and placebo T, rhGH and placebo T (GH), T and placebo GH (T), or rhGH and T (GHT).
interventionsThe leucine rate of appearance (index of proteolysis), nonoxidative leucine disposal rate (an index of protein synthesis), and leucine oxidation rate were measured with an infusion of l-[1-(13)C] leucine. Muscle biopsies for the measurement of gene expression were performed. Body composition and aerobic capacity (maximal oxygen capacity) were measured.
resultsSerum IGF-I levels increased significantly with GH and GHT (P < 0.001) compared with placebo. T increased significantly only in the T group (P = 0.028). Leucine rate of appearance and nonoxidative leucine disposal rate increased with GH (P = 0.015, P = 0.019) and GHT (P = 0.017, P = 0.02), but leucine oxidation did not change significantly in any treatment group. Midthigh muscle mass and maximal oxygen capacity increased (P < 0.04) with GHT only. Expression of muscle function genes did not change significantly, but the within-group comparisons revealed a significant increase of androgen receptor expression in the GHT group (P = 0.001).
conclusionThis study showed that 6-month treatment with low-dose GH alone or with T in healthy elderly men produces comparable increments in whole body protein turnover and protein synthesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.