ArticleJournal of the Royal Society, Interface2008
Rotavirus within day care centres in Oxfordshire, UK: characterization of partial immunity.
Article in Journal of the Royal Society, Interface, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Predicting the burden of co-infections in seasonally driven dynamics of pediatric rotavirus and norovirus.Infectious Disease Modelling · 2026Article
- Impact of dosing schedules on performance of rotavirus vaccines in Ghana.Science advances · 2024Article
- Impact of rotavirus vaccination in Malawi from 2012 to 2022 compared to model predictions before, during, and after the COVID-19 pandemic.medRxiv : the preprint server for health sciences · 2024Article
- Correlates of immune protection against human rotaviruses: natural infection and vaccination.Archives of virology · 2024Review
- Article
- Evaluating strategies to improve rotavirus vaccine impact during the second year of life in Malawi.Science translational medicine · 2019Article
- Health impact and cost-effectiveness of a domestically-produced rotavirus vaccine in India: A model based analysis.PloS one · 2017Article
- Re-evaluation of the cost-effectiveness and effects of childhood rotavirus vaccination in Norway.PloS one · 2017Article
- Correlates of protection against human rotavirus disease and the factors influencing protection in low-income settings.Mucosal immunology · 2015Review
- Dynamic modeling of cost-effectiveness of rotavirus vaccination, Kazakhstan.Emerging infectious diseases · 2014Article
- Observational Research in Childhood Infectious Diseases (ORChID): a dynamic birth cohort study.BMJ open · 2012Article
- Direct and indirect effects of rotavirus vaccination: comparing predictions from transmission dynamic models.PloS one · 2012Article
- A frequentist approach to estimating the force of infection for a respiratory disease using repeated measurement data from a birth cohort.Statistical methods in medical research · 2011Article
- Immune responses to rotavirus infection and vaccination and associated correlates of protection.The Journal of infectious diseases · 2011Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Repeated measures data for rotavirus infection in children within 14 day care centres (DCCs) in the Oxfordshire area, UK, are used to explore aspects of rotavirus transmission and immunity. A biologically realistic model for the transmission of infection is presented as a set of probability models suitable for application to the data. Two transition events are modelled separately: incidence and recovery. The complexity of the underlying mechanistic model is reflected in the choice of the fixed variables in the probability models. Parameter estimation was carried out using a Bayesian Markov chain Monte Carlo method. We use the parameter estimates obtained to build a profile of the natural history of rotavirus reinfection in an individual child. We infer that rotavirus transmission in children in DCCs is dependent on the DCC prevalence, with symptomatic infection of longer duration, but no more infectious per day of infectious period, than asymptomatic infection. There was evidence that a recent previous infection reduces the risk of disease and, to a lesser extent, reinfection, but not duration of infection. The results provide evidence that partial immunity to rotavirus infection develops over several time scales.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.