ArticleDevelopmental cell2008
Sensory signaling-dependent remodeling of olfactory cilia architecture in C. elegans.
Article in Developmental cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
86 citing papers in PubMed, 130 citations in OpenAlex.
- The role of the primary cilium in thyroid function and dysfunction with implications for thyroid disease.Histochemistry and cell biology · 2025Review
- C. elegans: An elegant experimental system for the study of cilia biology.Seminars in cell & developmental biology · 2025Review
- Multiple regulators constrain the abundance of Caenorhabditis elegans DLK-1 in ciliated sensory neurons.G3 (Bethesda, Md.) · 2025Article
- Modulation by NPY/NPF-like receptor underlies experience-dependent, sexually dimorphic learning.Nature communications · 2025Article
- Olfactory dysfunction as an early pathogenic indicator inFrontiers in aging neuroscience · 2024Article
- The G protein alpha chaperone and guanine-nucleotide exchange factor RIC-8 regulates cilia morphogenesis in Caenorhabditis elegans sensory neurons.PLoS genetics · 2023Article
- Primary cilia as dynamic and diverse signalling hubs in development and disease.Nature reviews. Genetics · 2023Review
- Article
- G protein-coupled receptor kinase-2 (GRK-2) controls exploration through neuropeptide signaling in Caenorhabditis elegans.PLoS genetics · 2023Article
- A negative feedback loop in the GPCR pathway underlies efficient coding of external stimuli.Molecular systems biology · 2022Article
- Balancing the length of the distal tip by septins is key for stability and signalling function of primary cilia.The EMBO journal · 2022Article
- Ciliary control of adipocyte progenitor cell fate regulates energy storage.Frontiers in cell and developmental biology · 2022Review
- Article
- Kinesin-2 transports Orco into the olfactory cilium of Drosophila melanogaster at specific developmental stages.PLoS genetics · 2021Article
- Anti-oxidant MitoQ rescue of AWB chemosensory neuron impairment in amicroPublication biology · 2021Article
- Structural Analysis of theFrontiers in neuroanatomy · 2021Article
- Enhanced expression of queuine tRNA-ribosyltransferase 1 (Annals of translational medicine · 2020Article
- The URX oxygen-sensing neurons inmicroPublication biology · 2020Article
- Long-term activity drives dendritic branch elaboration of a C. elegans sensory neuron.Developmental biology · 2020Article
- Cutting off ciliary protein import: intraflagellar transport after dendritic femtosecond-laser ablation.Molecular biology of the cell · 2020Article
26 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Nonmotile primary cilia are sensory organelles composed of a microtubular axoneme and a surrounding membrane sheath that houses signaling molecules. Optimal cellular function requires the precise regulation of axoneme assembly, membrane biogenesis, and signaling protein targeting and localization via as yet poorly understood mechanisms. Here, we show that sensory signaling is required to maintain the architecture of the specialized AWB olfactory neuron cilia in C. elegans. Decreased sensory signaling results in alteration of axoneme length and expansion of a membraneous structure, thereby altering the topological distribution of a subset of ciliary transmembrane signaling molecules. Signaling-regulated alteration of ciliary structures can be bypassed by modulation of intracellular cGMP or calcium levels and requires kinesin-II-driven intraflagellar transport (IFT), as well as BBS- and RAB8-related proteins. Our results suggest that compensatory mechanisms in response to altered levels of sensory activity modulate AWB cilia architecture, revealing remarkable plasticity in the regulation of cilia structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.