Evidence map›Paper›PMID 18477407›Full record

Trial reportBMC complementary and alternative medicine2008

Effect of exercise therapy on lipid profile and oxidative stress indicators in patients with type 2 diabetes.

Lorenzo A Gordon, Errol Y Morrison, Donovan A McGrowder, Ronald Young, Yeiny Terry Pena Fraser, Eslaen Martorell Zamora, Ruby L Alexander-Lindo, Rachael R Irving

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC complementary and alternative medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 18 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 18 syntheses or guidelines pooled it, 275 citations in OpenAlex.

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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lorenzo A GordonDepartment of Medicine, University of the West Indies, Kingston 7, Jamaica. lorenzogordon@yahoo.com
Errol Y Morrison
Donovan A McGrowder
Ronald Young
Yeiny Terry Pena Fraser
Eslaen Martorell Zamora
Ruby L Alexander-Lindo
Rachael R Irving
University of the West Indies · JMUniversity of the West Indies System · JM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundYoga has been shown to be a simple and economical therapeutic modality that may be considered as a beneficial adjuvant for type 2 diabetes mellitus. This study investigated the impact of Hatha yoga and conventional physical training (PT) exercise regimens on biochemical, oxidative stress indicators and oxidant status in patients with type 2 diabetes.

methodsThis prospective randomized study consisted of 77 type 2 diabetic patients in the Hatha yoga exercise group that were matched with a similar number of type 2 diabetic patients in the conventional PT exercise and control groups. Biochemical parameters such as fasting blood glucose (FBG), serum total cholesterol (TC), triglycerides, low-density lipoprotein (LDL), very low-density lipoproteins (VLDL) and high-density lipoprotein (HDL) were determined at baseline and at two consecutive three monthly intervals. The oxidative stress indicators (malondialdehyde - MDA, protein oxidation - POX, phospholipase A2 - PLA2 activity) and oxidative status [superoxide dismutase (SOD) and catalase activities] were measured.

resultsThe concentrations of FBG in the Hatha yoga and conventional PT exercise groups after six months decreased by 29.48% and 27.43% respectively (P < 0.0001) and there was a significant reduction in serum TC in both groups (P < 0.0001). The concentrations of VLDL in the managed groups after six months differed significantly from baseline values (P = 0.036). Lipid peroxidation as indicated by MDA significantly decreased by 19.9% and 18.1% in the Hatha yoga and conventional PT exercise groups respectively (P < 0.0001); whilst the activity of SOD significantly increased by 24.08% and 20.18% respectively (P = 0.031). There was no significant difference in the baseline and 6 months activities of PLA2 and catalase after six months although the latter increased by 13.68% and 13.19% in the Hatha yoga and conventional PT exercise groups respectively (P = 0.144).

conclusionThe study demonstrate the efficacy of Hatha yoga exercise on fasting blood glucose, lipid profile, oxidative stress markers and antioxidant status in patients with type 2 diabetes and suggest that Hatha yoga exercise and conventional PT exercise may have therapeutic preventative and protective effects on diabetes mellitus by decreasing oxidative stress and improving antioxidant status.

trial registrationAustralian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12608000217303.

Indexed as

Lipid PeroxidationOxidative StressYogaAdultAgedBiomarkersCholesterol, HDLCholesterol, LDLCholesterol, VLDLDiabetes Mellitus, Type 2Exercise TherapyFemaleGlutathione PeroxidaseGlycated HemoglobinHumansLipidsBiomarkersCholesterol, HDLCholesterol, LDLCholesterol, VLDLGlutathione PeroxidaseGlycated HemoglobinLipidsMalondialdehydeSuperoxide DismutaseTriglycerides

Identifiers

PMID18477407
PMCPMC2390515
OpenAlexW1993492653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.