ArticleMediators of inflammation1995
Nitric oxide as a mediator of inflammation?-You had better believe it.
Article in Mediators of inflammation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 71 citations in OpenAlex.
- Comparative Evaluation of Salivary Nitric Oxide in Caries-free and Affected Children before and after Total Oral Rehabilitation.International journal of clinical pediatric dentistry · 2026Article
- Mining toxicogenomic data for dose-responsive pathways: implications in advancing next-generation risk assessment.Frontiers in toxicology · 2023Article
- The clinical and immunologic features of pulmonary fibrosis in sarcoidosis.Translational research : the journal of laboratory and clinical medicine · 2012Article
- Carvacrol attenuates mechanical hypernociception and inflammatory response.Naunyn-Schmiedeberg's archives of pharmacology · 2012Article
- Pharmacodynamic interactions between recombinant mouse interleukin-10 and prednisolone using a mouse endotoxemia model.Journal of pharmaceutical sciences · 2005Article
- Effects of nonsteroidal anti-inflammatory drugs on Helicobacter pylori-infected gastric mucosae of mice: apoptosis, cell proliferation, and inflammatory activity.Infection and immunity · 2001Article
- Na+ - and Cl- -coupled active transport of nitric oxide synthase inhibitors via amino acid transport system B(0,+).The Journal of clinical investigation · 2001Article
- Nitric oxide function in atherosclerosis.Mediators of inflammation · 1997Article
- The puzzling inflammatory bowel disease: growing interest for mediators of inflammation.Mediators of inflammation · 1997Article
- Nitric oxide decreases intestinal haemorrhagic lesions in rat anaphylaxis independently of mast cell activation.Mediators of inflammation · 1997Article
- Failure of L-NAME to cause inhibition of nitric oxide synthesis: role of inducible nitric oxide synthase.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 1996Article
- Inhibition of NO-synthase and degranulation of rat omental mast cells in vitro.Mediators of inflammation · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide has enigmatic qualities in inflammation. In order to appreciate the precise contributions of nitric oxide to a pathophysiological process, one must account for enzyme source, coproduction of oxidants and antioxidant defences, time, rate of nitric oxide production, cellular source, peroxynitrite formation and effects on DNA (mutagenesis/apoptosis). We contend that there is ample evidence to consider nitric oxide as a molecular aggressor in inflammation, particularly chronic inflammation. Therapeutic benefit can be achieved by inhibition of inducible nitric oxide synthase and not the donation of additional nitric oxide. Furthermore, there is growing appreciation that nitric oxide and products derived thereof, are critical components linking the increased incidence of cancer in states of chronic inflammation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.