ArticleMediators of inflammation1995
Modulation of nitric oxide synthase activity in macrophages.
Article in Mediators of inflammation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 71 citations in OpenAlex.
- Regulation of Inducible Nitric Oxide Synthase (NOS2) Expression in Healthy and Inflamed Bowel: A Narrative Review.International journal of molecular sciences · 2026Review
- Studies of the Impact of the Bifidobacterium Species on Inducible Nitric Oxide Synthase Expression and Nitric Oxide Production in Murine Macrophages of the BMDM Cell Line.Probiotics and antimicrobial proteins · 2024Article
- Effects of Akt Activator SC79 on Human M0 Macrophage Phagocytosis and Cytokine Production.Cells · 2024Article
- Seasonal Immune Rhythms of head kidney and spleen cells in the freshwater Teleost,Fish and shellfish immunology reports · 2023Article
- Cytokine-Induced iNOS in A549 Alveolar Epithelial Cells: A Potential Role in COVID-19 Lung Pathology.Biomedicines · 2023Article
- Seasonal immune rhythm of leukocytes in the freshwater snakehead fish, Channa punctatus.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2022Article
- Effects of Natural Polyphenols on Oxidative Stress-Mediated Blood-Brain Barrier Dysfunction.Antioxidants (Basel, Switzerland) · 2022Review
- Evaluation of the sex steroids mediated modulation of leucocyte immune responses in an ophidianCurrent research in physiology · 2022Article
- Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages.Nature communications · 2021Article
- Photoperiodic manipulation modulates the innate and cell mediated immune functions in the fresh water snake, Natrix piscator.Scientific reports · 2020Article
- Selective and Sensocompatible Electrochemical Nitric Oxide Sensor with a Bilaminar Design.ACS sensors · 2019Article
- Neutrophils Are Central to Antibody-Mediated Protection against Genital Chlamydia.Infection and immunity · 2017Article
- IMMUNOSUPPRESIVE EFFECTS OF THE METHANOLIC EXTRACT OFAfrican journal of traditional, complementary, and alternative medicines : AJTCAM · 2017Article
- Daily and seasonal rhythms in immune responses of splenocytes in the freshwater snake, Natrix piscator.PloS one · 2015Article
- Dipterinyl calcium pentahydrate inhibits intracellular mycobacterial growth in human monocytes via the C-C chemokine MIP-1β and nitric oxide.Infection and immunity · 2013Article
- Immunomodulatory activity of ouabain in Leishmania leishmania amazonensis-infected Swiss mice.Parasitology research · 2013Article
- Article
- Extract from Calotropis procera latex activates murine macrophages.Journal of natural medicines · 2009Article
- IL-10 up-regulates nitric oxide (NO) synthesis by lipopolysaccharide (LPS)-activated macrophages: improved control of Trypanosoma cruzi infection.Clinical and experimental immunology · 1998Article
- The contribution of the immune system to parturition.Mediators of inflammation · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
L-Arginine is converted to the highly reactive and unstable nitric oxide (NO) and L-citrulline by an enzyme named nitric oxide synthase (NOS). NO decomposes into other nitrogen oxides such as nitrite (NO(2) (-)) and nitrate (NO(2) (-)), and in the presence of superoxide anion to the potent oxidizing agent peroxynitrite (ONOO(-)). Activated rodent macrophages are capable of expressing an inducible form of this enzyme (iNOS) in response to appropriate stimuli, i.e., lipopolysaccharide (LPS) and interferon-gamma (IFNgamma). Other cytokines can modulate the induction of NO biosynthesis in macrophages. NO is a major effector molecule of the anti-microbial and cytotoxic activity of rodent macrophages against certain micro-organisms and tumour cells, respectively. The NO synthesizing pathway has been demonstrated in human monocytes and other cells, but its role in host defence seems to be accessory. A delicate functional balance between microbial stimuli, host-derived cytokines and hormones in the microenvironment regulates iNOS expression. This review will focus mainly on the known and proposed mechanisms of the regulation of iNOS induction, and on agents that can modulate NO release once the active enzyme has been expressed in the macrophage.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.