ArticleProceedings of the National Academy of Sciences of the United States of America1991
Paired MyoD-binding sites regulate myosin light chain gene expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed, 209 citations in OpenAlex.
- Prediabetes-Associated Changes in Skeletal Muscle Function and Their Possible Links with Diabetes: A Literature Review.International journal of molecular sciences · 2023Review
- Incorporation of a skeletal muscle-specific enhancer in the regulatory region of Igf1 upregulates IGF1 expression and induces skeletal muscle hypertrophy.Scientific reports · 2018Article
- Activation of muscle enhancers by MyoD and epigenetic modifiers.Journal of cellular biochemistry · 2014Article
- The role of MyoD1 and histone modifications in the activation of muscle enhancers.Epigenetics · 2013Article
- Mechano growth factor (MGF) promotes proliferation and inhibits differentiation of porcine satellite cells (PSCs) by down-regulation of key myogenic transcriptional factors.Molecular and cellular biochemistry · 2012Article
- miR-206 integrates multiple components of differentiation pathways to control the transition from growth to differentiation in rhabdomyosarcoma cells.Skeletal muscle · 2012Article
- Elevated levels of active matrix metalloproteinase-9 cause hypertrophy in skeletal muscle of normal and dystrophin-deficient mdx mice.Human molecular genetics · 2011Article
- Differentiation and fiber type-specific activity of a muscle creatine kinase intronic enhancer.Skeletal muscle · 2011Article
- Myogenic regulatory factor response to resistance exercise volume in skeletal muscle.European journal of applied physiology · 2010Article
- Emerging parallels between stomatal and muscle cell lineages.Plant physiology · 2009Article
- Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3.The Journal of biological chemistry · 2009Article
- Synergistic up-regulation of muscle LIM protein expression in C2C12 and NIH3T3 cells by myogenin and MEF2C.Molecular genetics and genomics : MGG · 2009Review
- Impact of repeated bouts of eccentric exercise on myogenic gene expression.European journal of applied physiology · 2007Article
- The chemokine Sdf-1 and its receptor Cxcr4 are required for formation of muscle in zebrafish.BMC developmental biology · 2007Article
- Ab initio identification of putative human transcription factor binding sites by comparative genomics.BMC bioinformatics · 2005Article
- Skeletal myosin heavy chain function in cultured lung myofibroblasts.The Journal of cell biology · 2003Article
- Differentiation-dependent mechanisms of transcriptional regulation of the catalytic subunit of phosphorylase kinase.The Biochemical journal · 2002Article
- Increased myogenic repressor Id mRNA and protein levels in hindlimb muscles of aged rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2002Article
- Molecular dissection of DNA sequences and factors involved in slow muscle-specific transcription.Molecular and cellular biology · 2001Article
- TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3.Genes & development · 2001Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The muscle-specific enhancer element located downstream of the myosin light chain (MLC) locus encoding MLC1 and MLC3 contains three binding sites (A, B, and C) for the myogenic determination factor MyoD. A 173-base-pair region of the MLC gene enhancer, including these three sites, retains full enhancer function when transfected into muscle cells. Whereas mutation of either upstream MyoD binding site (A or B) has a mild effect on muscle-specific enhancer activity, mutation of the third MyoD binding site (C) substantially weakens the enhancer, both in muscle cells or in nonmuscle cells cotransfected with a MyoD, myogenin, or myf5 expression vector. Site C is necessary but insufficient, since double mutation of two MyoD binding sites (A plus B) abrogates enhancer activity. Thus, site C requires either site A or B for enhancer function. This study shows a hierarchy of function among the three MyoD binding sites in the MLC enhancer. We propose that a protein-DNA complex is formed with at least two of these sites (A and C or B and C) to effect activation of the locus encoding MLC1/3 during myogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.