ArticleProceedings of the National Academy of Sciences of the United States of America2008
Fecal transmission of AA amyloidosis in the cheetah contributes to high incidence of disease.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53 citing papers in PubMed, 123 citations in OpenAlex.
- Modelling human proteostasis and organelle homeostasis disorders in yeast and its application in drug discovery.FEMS yeast research · 2026Review
- High prevalence of renal amyloidosis in cats in an overcrowded colony.The Journal of veterinary medical science · 2025Article
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- The worldwide need for amyloid diagnosis in animals.Journal of biosciences · 2023Article
- Histological evaluation of the distribution of systemic AA-amyloidosis in nine domestic shorthair cats.PloS one · 2023Article
- AA-amyloidosis in cats (Felis catus) housed in shelters.PloS one · 2023Article
- Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter.Nature communications · 2022Article
- Article
- AA amyloid in human food chain is a possible biohazard.Scientific reports · 2021Article
- Aggregation of Mouse Serum Amyloid A Protein Was Promoted by Amyloid-Enhancing Factors with the More Genetically Homologous Serum Amyloid A.International journal of molecular sciences · 2021Article
- p53, A Victim of the Prion Fashion.Cancers · 2021Review
- The prion-like phenomenon in Alzheimer's disease: Evidence of pathology transmission in humans.PLoS pathogens · 2020Review
- Dietary Intake of Rosmarinic Acid Increases Serum Inhibitory Activity in Amyloid A Aggregation and Suppresses Deposition in the Organs of Mice.International journal of molecular sciences · 2020Article
- Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids.Nature communications · 2019Article
- Amyloidosis-inducing activity of blood cells in mouse AApoAII amyloidosis.Experimental animals · 2018Article
- Rab GTPases and cell division.Small GTPases · 2018Review
- Noncerebral Amyloidoses: Aspects on Seeding, Cross-Seeding, and Transmission.Cold Spring Harbor perspectives in medicine · 2018Review
- Post mortem findings and their relation to AA amyloidosis in free-ranging Herring gulls (Larus argentatus).PloS one · 2018Article
- A new perspective on the pathogenesis of chronic renal disease in captive cheetahs (Acinonyx jubatus).PloS one · 2018Article
- Systemic AA amyloidosis in the red fox (Vulpes vulpes).Protein science : a publication of the Protein Society · 2017Article
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11 authors at 7 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
AA amyloidosis is one of the principal causes of morbidity and mortality in captive cheetahs (Acinonyx jubatus), which are in danger of extinction, but little is known about the underlying mechanisms. Given the transmissible characteristics of AA amyloidosis, transmission between captive cheetahs may be a possible mechanism involved in the high incidence of AA amyloidosis. In this study of animals with AA amyloidosis, we found that cheetah feces contained AA amyloid fibrils that were different from those of the liver with regard to molecular weight and shape and had greater transmissibility. The infectious activity of fecal AA amyloid fibrils was reduced or abolished by the protein denaturants 6 M guanidine.HCl and formic acid or by AA immunodepletion. Thus, we propose that feces are a vehicle of transmission that may accelerate AA amyloidosis in captive cheetah populations. These results provide a pathogenesis for AA amyloidosis and suggest possible measures for rescuing cheetahs from extinction.
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