ArticleNeurology2008
Altered fMRI activation during mental rotation in those at genetic risk for Alzheimer disease.
Article in Neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cognitive Functioning of Unaffected First-degree Relatives of Individuals With Late-onset Alzheimer's Disease: A Systematic Literature Review and Meta-analysis.Neuropsychology review · 2023Pooled it
- Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis.Frontiers in aging neuroscience · 2023Pooled it
- Time/Movement Estimation and Mental Rotation Tasks as Early Cognitive Markers in Alzheimer's Disease.Brain and behavior · 2025Article
- Recovery from the damage of cranial radiation modulated by memantine, an NMDA receptor antagonist, combined with hyperbaric oxygen therapy.Neuro-oncology · 2023Article
- Distinct Brain Functional Impairment Patterns Between Suspected Non-Alzheimer Disease Pathophysiology and Alzheimer's Disease: A Study Combining Static and Dynamic Functional Magnetic Resonance Imaging.Frontiers in aging neuroscience · 2020Article
- Family History of Alzheimer's Disease is Associated with Impaired Perceptual Discrimination of Novel Objects.Journal of Alzheimer's disease : JAD · 2017Article
- Transcranial Direct Current Stimulation of the Temporoparietal Junction and Inferior Frontal Cortex Improves Imitation-Inhibition and Perspective-Taking with no Effect on the Autism-Spectrum Quotient Score.Frontiers in behavioral neuroscience · 2017Article
- Gene expression parallels synaptic excitability and plasticity changes in Alzheimer's disease.Frontiers in cellular neuroscience · 2015Review
- Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer's disease.Neurobiology of aging · 2014Article
- Phase-specific brain change of spatial working memory processing in genetic and ultra-high risk groups of schizophrenia.Schizophrenia bulletin · 2012Article
- Preclinical Alzheimer disease: identification of cases at risk among cognitively intact older individuals.BMC medicine · 2012Review
- Effects of risk genes on BOLD activation in presymptomatic carriers of familial Alzheimer's disease mutations during a novelty encoding task.Cerebral cortex (New York, N.Y. : 1991) · 2011Article
- Two-stage decompositions for the analysis of functional connectivity for fMRI with application to Alzheimer's disease risk.NeuroImage · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveThis study was undertaken to examine differential functional MRI patterns in those at genetic risk for Alzheimer disease (AD), specifically investigating parietal lobe activation, a brain region with changes noted in the early stages of AD.
methodsThis study uses functional MRI to investigate blood oxygenation level dependent changes in the parietal lobe in a high-risk sample of 18 asymptomatic offspring of autopsy-confirmed AD cases, compared to 15 matched controls. The cognitive activation paradigm was a mental rotation task, which requires individuals to rotate three-dimensional cube stimuli to judge their similarity.
resultsWe found no differences in either reaction time or performance accuracy between groups. However, the at-risk individuals showed increases in activation in the right superior parietal lobule (BA 7), the right insula (BA 13), the right middle frontal gyrus (BA 10), and the right inferior frontal gyrus (BA 47).
conclusionsWe present evidence for a compensatory mechanism for those at increased risk for Alzheimer disease (AD). This study examines and confirms parietal changes with increased risk for late-onset AD, despite normal cognitive performance. Added to the previous findings from this group, these results demonstrate the sensitivity of functional imaging measures to brain changes that are not yet reflected in cognitive performance, which may ultimately serve as an important indicator of disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.