ArticleThe Journal of general physiology2008
Position and role of the BK channel alpha subunit S0 helix inferred from disulfide crosslinking.
Article in The Journal of general physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Fifty years of gating currents and channel gating.The Journal of general physiology · 2023Review
- The Large-Conductance, Calcium-Activated Potassium Channel: A Big Key Regulator of Cell Physiology.Frontiers in physiology · 2021Review
- Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel.The Journal of general physiology · 2017Review
- β1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- Positions of the cytoplasmic end of BK α S0 helix relative to S1-S6 and of β1 TM1 and TM2 relative to S0-S6.The Journal of general physiology · 2015Article
- BK channels: multiple sensors, one activation gate.Frontiers in physiology · 2015Review
- Oxidative modulation of voltage-gated potassium channels.Antioxidants & redox signaling · 2014Review
- The smooth muscle-type β1 subunit potentiates activation by DiBAC4(3) in recombinant BK channels.Channels (Austin, Tex.) · 2014Article
- Transduction of voltage and Ca2+ signals by Slo1 BK channels.Physiology (Bethesda, Md.) · 2013Review
- Orientations and proximities of the extracellular ends of transmembrane helices S0 and S4 in open and closed BK potassium channels.PloS one · 2013Article
- Positions of β2 and β3 subunits in the large-conductance calcium- and voltage-activated BK potassium channel.The Journal of general physiology · 2013Article
- Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels.The Journal of general physiology · 2012Article
- Large conductance, calcium- and voltage-gated potassium (BK) channels: regulation by cholesterol.Pharmacology & therapeutics · 2012Review
- On the simple random-walk models of ion-channel gate dynamics reflecting long-term memory.European biophysics journal : EBJ · 2012Article
- Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1.The Journal of general physiology · 2012Article
- Regulation of Voltage-Activated K(+) Channel Gating by Transmembrane β Subunits.Frontiers in pharmacology · 2012Article
- Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- BK-type calcium-activated potassium channels: coupling of metal ions and voltage sensing.The Journal of physiology · 2010Review
- Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channel.The Journal of general physiology · 2010Article
Corrections and comments
- Commented on byS0, where is it?2008
Authors and funding
7 authors.
Funding
Abstract
The position and role of the unique N-terminal transmembrane (TM) helix, S0, in large-conductance, voltage- and calcium-activated potassium (BK) channels are undetermined. From the extents of intra-subunit, endogenous disulfide bond formation between cysteines substituted for the residues just outside the membrane domain, we infer that the extracellular flank of S0 is surrounded on three sides by the extracellular flanks of TM helices S1 and S2 and the four-residue extracellular loop between S3 and S4. Eight different double cysteine-substituted alphas, each with one cysteine in the S0 flank and one in the S3-S4 loop, were at least 90% disulfide cross-linked. Two of these alphas formed channels in which 90% cross-linking had no effect on the V(50) or on the activation and deactivation rate constants. This implies that the extracellular ends of S0, S3, and S4 are close in the resting state and move in concert during voltage sensor activation. The association of S0 with the gating charge bearing S3 and S4 could contribute to the considerably larger electrostatic energy required to activate the BK channel compared with typical voltage-gated potassium channels with six TM helices.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.