ArticleThe Journal of cell biology2008
Tektin 2 is required for central spindle microtubule organization and the completion of cytokinesis.
Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Obesity- and tumor-derived signals drive cancer-associated state transitions in breast mesenchymal stromal/stem cells reprogrammed by IL1RA or JAK inhibition.Experimental hematology & oncology · 2026Article
- Tekt2 regulates hair cell development and function by maintaining normal kinocilium morphology in zebrafish.Frontiers in cell and developmental biology · 2026Article
- Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish.Cell death & disease · 2022Article
- KIF5B modulates central spindle organization in late-stage cytokinesis in chondrocytes.Cell & bioscience · 2019Article
- Chromosome missegregation during anaphase triggers p53 cell cycle arrest through histone H3.3 Ser31 phosphorylation.Nature cell biology · 2016Article
- Insights into the structure and function of ciliary and flagellar doublet microtubules: tektins, Ca2+-binding proteins, and stable protofilaments.The Journal of biological chemistry · 2014Article
- Molecular cloning and subcellular localization of Tektin2-binding protein 1 (Ccdc 172) in rat spermatozoa.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2014Article
- Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids.Nature · 2013Article
- Cep57 protein is required for cytokinesis by facilitating central spindle microtubule organization.The Journal of biological chemistry · 2013Article
- Amphiastral mitotic spindle assembly in vertebrate cells lacking centrosomes.Current biology : CB · 2011Article
- Centrosome biogenesis continues in the absence of microtubules during prolonged S-phase arrest.Journal of cellular physiology · 2010Article
- Kinesins to the core: The role of microtubule-based motor proteins in building the mitotic spindle midzone.Seminars in cell & developmental biology · 2010Review
- Mutations in a gene encoding a midbody protein in binucleated Reed-Sternberg cells of Hodgkin lymphoma.Cell cycle (Georgetown, Tex.) · 2010Article
- The 3Ms of central spindle assembly: microtubules, motors and MAPs.Nature reviews. Molecular cell biology · 2009Review
- Article
- The tektin family of microtubule-stabilizing proteins.Genome biology · 2008Review
- Antisperm protein targets in azoospermia men.Journal of human reproductive sciencesArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
During anaphase, the nonkinetochore microtubules in the spindle midzone become compacted into the central spindle, a structure which is required to both initiate and complete cytokinesis. We show that Tektin 2 (Tek2) associates with the spindle poles throughout mitosis, organizes the spindle midzone microtubules during anaphase, and assembles into the midbody matrix surrounding the compacted midzone microtubules during cytokinesis. Tek2 small interfering RNA (siRNA) disrupts central spindle organization and proper localization of MKLP1, PRC1, and Aurora B to the midzone and prevents the formation of a midbody matrix. Video microscopy revealed that loss of Tek2 results in binucleate cell formation by aberrant fusion of daughter cells after cytokinesis. Although a myosin II inhibitor, blebbistatin, prevents actin-myosin contractility, the microtubules of the central spindle are compacted. Strikingly, Tek2 siRNA abolishes this actin-myosin-independent midzone microtubule compaction. Thus, Tek2-dependent organization of the central spindle during anaphase is essential for proper midbody formation and the segregation of daughter cells after cytokinesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.