Evidence map›Paper›PMID 18474353›Full record

ArticleCell host & microbe2008

CO-opting the host HO-1 pathway in tuberculosis and malaria.

Photini Sinnis, Joel D Ernst

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Tuberculosis Comorbidity with Communicable and Noncommunicable Diseases.Cold Spring Harbor perspectives in medicine · 2015
    Review
  4. Heme oxygenase-1 regulates the immune response to influenza virus infection and vaccination in aged mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Photini SinnisDepartment of Medical Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA.
Joel D Ernst
New York University · US

Funding

Structure and Function of the Circumsporozoite ProteinR01AI056840 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SINNIS, PHOTINI · 2005 to 2014
$3.8M
NIAID NIH HHS R01 AI056840
6 · The paper itself

Abstract

Infection with Mycobacterium tuberculosis and Plasmodium species results in upregulation of the host heme oxygenase-1 pathway. In tuberculosis infection, this leads to upregulation of the bacterial "dormancy regulon," whereas in malaria, it enhances the efficiency with which sporozoites develop into exoerythrocytic stages. Here we discuss these findings as well as some of the interesting questions they raise.

Indexed as

AnimalsCarbon MonoxideHeme Oxygenase-1HumansMalariaMycobacterium tuberculosisPlasmodiumTuberculosisCarbon MonoxideHeme Oxygenase-1

Identifiers

PMID18474353
PMCPMC11863669
OpenAlexW2051000299

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.