ArticleInternational journal of radiation oncology, biology, physics2008
Electron paramagnetic resonance oxygen image hypoxic fraction plus radiation dose strongly correlates with tumor cure in FSa fibrosarcomas.
Article in International journal of radiation oncology, biology, physics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 84 citations in OpenAlex.
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- A Novel Approach to In Vivo EPR Spectroscopy for Repeatable Assessments of Oxygenation Levels in Tumors at Any Depth: Preliminary Feasibility Studies Utilizing a Multisite Oxygen Sensor Inside HDR Brachytherapy Needles.Advances in experimental medicine and biology · 2026Article
- Evaluations of an Early Change in Tumor Pathophysiology in Response to Radiotherapy with Oxygen Enhanced Electron Paramagnetic Resonance Imaging (OE EPRI).Molecular imaging and biology · 2024Article
- Evaluating Tumor Hypoxia Radiosensitization Via Electron Paramagnetic Resonance Oxygen Imaging (EPROI).Molecular imaging and biology · 2024Article
- Direct Measurement and Imaging of Redox Status with Electron Paramagnetic Resonance.Antioxidants & redox signaling · 2024Article
- Nondestructive, longitudinal, 3D oxygen imaging of cells in a multi-well plate using pulse electron paramagnetic resonance imaging.Npj imaging · 2024Article
- In vitro oxygen imaging of acellular and cell-loaded beta cell replacement devices.Scientific reports · 2023Article
- 4D-image reconstruction directly from limited-angular-range data in continuous-wave electron paramagnetic resonance imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2023Article
- The optimalEuropean journal of nuclear medicine and molecular imaging · 2022Article
- The Role of Imaging Biomarkers to Guide Pharmacological Interventions Targeting Tumor Hypoxia.Frontiers in pharmacology · 2022Review
- Bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations.PLoS computational biology · 2021Article
- Small Animal IMRT Using 3D-Printed Compensators.International journal of radiation oncology, biology, physics · 2021Article
- Heterogeneity of radiation response in mesenchymal subtype glioblastoma: molecular profiling and reactive oxygen species generation.Journal of neuro-oncology · 2021Article
- Improving Tumor Hypoxia Location inRadiology. Imaging cancer · 2021Article
- Merging Preclinical EPR Tomography with other Imaging Techniques.Cell biochemistry and biophysics · 2019Article
- Oxygen-Guided Radiation Therapy.International journal of radiation oncology, biology, physics · 2019Article
- Data processing of 3D and 4D in-vivo electron paramagnetic resonance imaging co-registered with ultrasound. 3D printing as a registration tool.Computers & electrical engineering : an international journal · 2019Article
- Article
- Biology of pancreatic stellate cells-more than just pancreatic cancer.Pflugers Archiv : European journal of physiology · 2017Review
- In vivo preclinical cancer and tissue engineering applications of absolute oxygen imaging using pulse EPR.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2017Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTumor hypoxia has long been known to produce resistance to radiation. In this study, electron paramagnetic resonance (EPR) oxygen imaging was investigated for its power to predict the success of tumor control according to tumor oxygenation level and radiation dose. METHODS AND MATERIALS: A total of 34 EPR oxygen images were obtained from the legs of C3H mice bearing 0.5-cm(3) FSa fibrosarcomas under both normal (air breathing) and clamped tumor conditions. Under the same conditions as those during which the images were obtained, the tumors were irradiated to a variety of doses near the FSa dose at which 50% of tumors were cured. Tumor tissue was distinguished from normal tissue using co-registration of the EPR oxygen images with spin-echo magnetic resonance imaging of the tumor and/or stereotactic localization. The tumor voxel statistics in the EPR oxygen image included the mean and median partial pressure of oxygen and the fraction of tumor voxels below the specified partial pressure of oxygen values of 3, 6, and 10 mm Hg. Bivariate logistic regression analysis using the radiation dose and each of the EPR oxygen image statistics to determine which best separated treatment failure from success.
resultsThe measurements of the dose at which 50% of tumors were cured were similar to those found in published data for this syngeneic tumor. Bivariate analysis of 34 tumors demonstrated that tumor cure correlated with dose (p = 0.004) and with a <10 mm Hg hypoxic fraction (p = 0.023).
conclusionOur results have shown that, together, radiation dose and EPR image hypoxic fraction separate the population of FSa fibrosarcomas that are cured from those that fail, thus predicting curability.
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