ArticleFEBS letters2008
Metabolic and signaling properties of an Itpk gene family in Glycine max.
Article in FEBS letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Genome wide identification and analysis of inositol tetrakisphosphate kinase (ITPK) gene family in Triticum aestivum L.PloS one · 2026Article
- A minimum catalytic unit for synthesis of InsP6 and 5-PP-InsP5 in Arabidopsis.The Biochemical journal · 2025Article
- Biotechnological approaches to reduce the phytic acid content in millets to improve nutritional quality.Planta · 2024Review
- Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlier AtITPK4.The Biochemical journal · 2023Article
- Structural and catalytic analyses of the InsPFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- CRISPR/Cas9 mediated disruption ofJournal of advanced research · 2022Article
- Inositol phosphate kinases in the eukaryote landscape.Advances in biological regulation · 2021Article
- Gene editing of three BnITPK genes in tetraploid oilseed rape leads to significant reduction of phytic acid in seeds.Plant biotechnology journal · 2020Article
- Allelic Variants of CRISPR/Cas9 Induced Mutation in an Inositol Trisphosphate 5/6 Kinase Gene Manifest Different Phenotypes in Barley.Plants (Basel, Switzerland) · 2020Article
- Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops?Plants (Basel, Switzerland) · 2020Review
- PI signal transduction and ubiquitination respond to dehydration stress in the red seaweed Gloiopeltis furcata under successive tidal cycles.BMC plant biology · 2019Article
- Seed targeted RNAi-mediated silencing of GmMIPS1 limits phytate accumulation and improves mineral bioavailability in soybean.Scientific reports · 2019Article
- Molecular characterization, modeling, and docking analysis of late phytic acid biosynthesis pathway gene,3 Biotech · 2018Article
- RNAi-Mediated Downregulation of Inositol Pentakisphosphate Kinase (Frontiers in plant science · 2018Article
- Characterization and molecular modeling of Inositol 1,3,4 tris phosphate 5/6 kinase-2 from3 Biotech · 2018Article
- Seed Biofortification and Phytic Acid Reduction: A Conflict of Interest for the Plant?Plants (Basel, Switzerland) · 2015Review
- Hormonal Regulation and Expression Profiles of Wheat Genes Involved during Phytic Acid Biosynthesis Pathway.Plants (Basel, Switzerland) · 2015Article
- Molecular basis for the integration of inositol phosphate signaling pathways via human ITPK1.Advances in enzyme regulation · 2009Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We have cloned and characterized four Itpk genes from soybean. All four recombinant Itpk proteins showed canonical Ins(1,3,4)P3 5/6-kinase activity, but a kinetic analysis raised questions about its biological significance. Instead, we provide evidence that one alternative biological role for soybean Itpks is to interconvert the Cl(-) channel inhibitor, Ins(3,4,5,6)P4, and its metabolic precursor, Ins(1,3,4,5,6)P5, within a substrate cycle. The soybean Itpks also phosphorylated Ins(3,4,6)P3 to Ins(1,3,4,6)P4 which was further phosphorylated to Ins(1,3,4,5,6)P5 by soybean Ipk2. Thus, soybean Itpks may participate in an inositol lipid-independent pathway of InsP6 synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.