ReviewCurrent psychiatry reports2008
Genetics of clinical features and subtypes of schizophrenia: a review of the recent literature.
Review in Current psychiatry reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Genetic insights into schizophrenia: ERBB4 and GABRB2 polymorphisms in the Lebanese population.IBRO neuroscience reports · 2025Article
- The genetic basis of onset age in schizophrenia: evidence and models.Frontiers in genetics · 2023Review
- Neurobehavioral risk factors influence prevalence and severity of hazardous substance use in youth at genetic and clinical high risk for psychosis.Frontiers in psychiatry · 2023Article
- Glycated Haemoglobin Is Associated With Poorer Cognitive Performance in Patients With Recent-Onset Psychosis.Frontiers in psychiatry · 2020Article
- Parsing psychosis subtypes through investigations of rare genetic variants.EBioMedicine · 2016Article
- DNA methylation patterns of protein-coding genes and long non-coding RNAs in males with schizophrenia.Molecular medicine reports · 2015Article
- DSM-IV "criterion A" schizophrenia symptoms across ethnically different populations: evidence for differing psychotic symptom content or structural organization?Culture, medicine and psychiatry · 2014Article
- Male-specific association between dopamine receptor D4 gene methylation and schizophrenia.PloS one · 2014Article
- Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.The American journal of psychiatry · 2012Article
- Antioxidant defense system and family environment in adolescents with family history of psychosis.BMC psychiatry · 2012Article
- Kraepelin was right: a latent class analysis of symptom dimensions in patients and controls.Schizophrenia bulletin · 2012Article
- Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis.PloS one · 2012Article
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- Understanding the complex etiologies of developmental disorders: behavioral and molecular genetic approaches.Journal of developmental and behavioral pediatrics : JDBP · 2010Review
- Association study of SNAP25 and schizophrenia in Irish family and case-control samples.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- A genome-wide investigation of SNPs and CNVs in schizophrenia.PLoS genetics · 2009Article
- Schizophrenia genomics and proteomics: are we any closer to biomarker discovery?Behavioral and brain functions : BBF · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since its earliest descriptions, schizophrenia has been thought to be clinically heterogeneous. Symptomatic features and subtypes tend to aggregate in families, suggesting that genetic factors contribute to individual differences in illness presentation. Over the past 5 years, evidence from genetic linkage and association studies has mounted to suggest that some susceptibility genes are etiologic factors for more or less specific illness subtypes. Furthermore, modifier genes may affect clinical features dimensionally only after a given patient is already affected with the illness. In this paper, we review recent findings supporting the existence of such "modifier" genes. To date, DTNBP1 has provided the greatest evidence of illness modification, as associations with negative and cognitive symptoms and worse outcome have been published in independent samples. Future directions include using whole-genome association studies to search for genetic modifiers of schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.