ArticleWorld journal of gastroenterology2008
Control of gallbladder contractions by cholecystokinin through cholecystokinin-A receptors on gallbladder interstitial cells of Cajal.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Presence and significance of telocytes in cholelithiasis and biliary dilatation in benign biliary disorders.Scientific reports · 2024Article
- Emodin repairs interstitial cells of Cajal damaged by cholelithiasis in the gallbladder.Frontiers in pharmacology · 2024Article
- Impact of interstitial cells of Cajal on slow wave and gallbladder contractility in a guinea pig model of acute cholecystitis.World journal of gastrointestinal surgery · 2023Article
- Smooth muscle cells, interstitial cells and neurons in the gallbladder (GB): Functional syncytium of electrical rhythmicity and GB motility (Review).International journal of molecular medicine · 2023Review
- Gut Bacteria and Neurotransmitters.Microorganisms · 2022Review
- Article
- Neutrophil depletion reduces interstitial cajal-like cell injury and alleviates inflammation-induced motor dysfunction in guinea-pig gallbladder during acute cholecystitis.Iranian journal of basic medical sciences · 2022Article
- Targeting the Gut in Obesity: Signals from the Inner Surface.Metabolites · 2022Review
- Changes in the interstitial cells of Cajal in the gallbladder of guinea pigs fed a lithogenic diet.Experimental and therapeutic medicine · 2021Article
- Cholesterol gallstones: Focusing on the role of interstitial Cajal-like cells.World journal of clinical cases · 2021Review
- Effects of Cholecystokinin (CCK) on Gut Motility in the Stomachless Fish Ballan Wrasse (Frontiers in neuroscience · 2019Article
- Ursodeoxycholic acid protects interstitial Cajal-like cells in the gallbladder from undergoing apoptosis by inhibiting TNF-α expression.Acta pharmacologica Sinica · 2018Article
- Telocytes and interstitial cells of Cajal in the biliary system.Journal of cellular and molecular medicine · 2018Review
- C-Kit expression in the gallbladder of guinea pig with chronic calculous cholecystitis and the effect of Artemisia capillaris Thunb on interstitial cells of Cajal.Iranian journal of basic medical sciences · 2016Article
- The role of interstitial Cajal-like cells in the formation of cholesterol stones in guinea pig gallbladder.Hepatology international · 2015Article
- Cholesterol gallstone disease: focusing on the role of gallbladder.Laboratory investigation; a journal of technical methods and pathology · 2015Review
- Decreased SCF/c-kit signaling pathway contributes to loss of interstitial cells of Cajal in gallstone disease.International journal of clinical and experimental medicine · 2014Article
- Telocytes: new insight into the pathogenesis of gallstone disease.Journal of cellular and molecular medicine · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo identify the cholecystokinin (CCK)-A receptors (CCK-AR) on the guniea pig gallbladder interstitial cells of cajal (ICC) and to study CCK-8 induced gallbladder muscle strip contractions through the CCK-AR.
methodsThe existence of CCK-AR was examined by immunohistofluorescence on sectioned tissue and cultured cells. In vitro contractile response of guinea pig gallbladder muscle strips and the strips with ICC removed were also studied with CCK-8 receptors added.
resultsIn tissue sections, intensely CCKAR-immunoreactive interstitial cells were found mainly in the muscular layers. In cultured cell sections, distinctive double staining of C-kit and CCK-AR ICCs were found. When we removed the ICC of the gallbladder, CCK-8 induced muscle strip contraction dose response curve significantly shifted to the right.
conclusionWe proved that both the existence of CCK-AR on the guinea pig gallbladder ICC and CCK evoked contraction are mediated through direct action on CCK-AR on the gallbladder ICC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.