ArticleParasitology research2008
Glycogen branching enzyme: a novel deltamethrin resistance-associated gene from Culex pipiens pallens.
Article in Parasitology research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Transcriptomic and proteomic analysis of pyrethroid resistance in the CKR strain of Aedes aegypti.PLoS neglected tropical diseases · 2021Article
- NYD-OP7/PLC regulatory signaling pathway regulates deltamethrin resistance in Culex pipiens pallens (Diptera: Culicidae).Parasites & vectors · 2018Article
- Laboratory development of permethrin resistance and cross-resistance pattern of Culex quinquefasciatus to other insecticides.Parasitology research · 2015Article
- Cloning and characterization of prophenoloxidase A3 (proPOA3) from Culex pipiens pallens.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2012Article
- Functional characterization of an arrestin gene on insecticide resistance of Culex pipiens pallens.Parasites & vectors · 2012Article
- Cloning and overexpression of transferrin gene from cypermethrin-resistant Culex pipiens pallens.Parasitology research · 2012Article
- Molecular cloning and preliminary function study of iron responsive element binding protein 1 gene from cypermethrin-resistant Culex pipiens pallens.Parasites & vectors · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The glycogen branching enzyme (GBE) gene has been cloned from Culex pipiens pallens. An open reading frame of 2,070 bp was found to encode a putative 689 amino acid protein. The deduced amino acid sequence shares 82% and 60% identity with GBE genes from Aedes aegypti and Homo sapiens. Transcript expression of GBE was determined by real-time polymerase chain reaction in deltamethrin-susceptible and deltamethrin-resistant strains of the Culex mosquito. The results demonstrated that this gene has 19.7-fold higher expression in deltamethrin-resistant strain. Unexpectedly, the following study showed that cell proliferation decreased obviously in the GBE overexpression group compared to the empty vector control or the unrelated gene when treated by deltamethrin in the mosquito C6/36 cells whose mechanism is still unexplained. Our study provides the first direct evidence that GBE gene may play some role in the development of deltamethrin resistance in C. pipiens pallens.
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Registered trials
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