ArticleMediators of inflammation1994
Effects of the Bacterial Extract OM-85 on Phagocyte Functions and the Stress Response.
Article in Mediators of inflammation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Viral infections and wheezing-asthma inception in childhood: is there a role for immunomodulation by oral bacterial lysates?Clinical and translational allergy · 2020Review
- Selective activation of human dendritic cells by OM-85 through a NF-kB and MAPK dependent pathway.PloS one · 2013Article
- Phagocytosis of Pseudomonas aeruginosa fails to elicit heat shock protein expression in human monocytes.Inflammation · 1996Article
- Presence of hsp65 in bacterial extracts (OM-89): a possible mediator of orally-induced tolerance?Experientia · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of the bacterial extract OM-85 on the respiratory burst, intracellular calcium and the stress response have been investigated in human peripheral blood monocytes from normal donors. Activation of the respiratory burst during bacterial phagocytosis has been previously associated with heat shock/stress proteins synthesis. Whereas OM-85 stimulated superoxide production and increased Ca(2+) mobilization, it fared to induce synthesis of classical HSPs. The lack of stress protein induction was observed even in the presence of iron which potentiates both oxidative injury and stress protein induction during bacterial phagocytosis. However OM-85 induced a 75-78 kDa protein, which is likely to be a glucose regulated protein (GRP78), and enhanced intracellular expression of interleukin-lbeta precursor.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.