ArticleMediators of inflammation1997
Anti-inflammatory effect of glucose-mannose binding lectins isolated from Brazilian beans.
Article in Mediators of inflammation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 102 citations in OpenAlex.
- Revisiting Proteus 2.0: Two Decades of Pioneering Lectin Crystallography at BioMol-Lab in Northeast Brazil.ACS omega · 2025Review
- Therapeutic anti-inflammatory immune potentials of some seaweeds extracts on chemically induced liver injury in mice.Scientific reports · 2025Article
- From inflammation to immune regulation: The dual nature of dietary lectins in health and disease.Heliyon · 2024Review
- Glycosylated SARs Cov 2 interaction with plant lectins.Glycoconjugate journal · 2024Review
- Article
- The anti-inflamatory effect of Andira anthelmia lectin in rats involves inhibition of the prostanoid pathway, TNF-α and lectin domain.Molecular biology reports · 2022Article
- Plant lectins as potent Anti-coronaviruses, Anti-inflammatory, antinociceptive and antiulcer agents.Saudi journal of biological sciences · 2022Review
- Article
- ConA-Like Lectins: High Similarity Proteins as Models to Study Structure/Biological Activities Relationships.International journal of molecular sciences · 2018Review
- Anti-inflammatory and antinociceptive activities ofBiochimie open · 2016Article
- A novel N-acetyl-glucosamine lectin of Lonchocarpus araripensis attenuates acute cellular inflammation in mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Dual effects of a lectin from the green seaweed Caulerpa cupressoides var. lycopodium on inflammatory mediators in classical models of inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
- Dioclea violacea lectin ameliorates oxidative stress and renal dysfunction in an experimental model of acute kidney injury.American journal of translational research · 2015Article
- Structural studies of an anti-inflammatory lectin from Canavalia boliviana seeds in complex with dimannosides.PloS one · 2014Article
- Purification, partial characterization and immobilization of a mannose-specific lectin from seeds of Dioclea lasiophylla mart.Molecules (Basel, Switzerland) · 2013Article
- Effects of Canavalia lectins on acute inflammation in sensitized and non-sensitized rats.Inflammation · 2013Article
- Effect of leguminous lectins on the growth of Rhizobium tropici CIAT899.Molecules (Basel, Switzerland) · 2013Article
- Molecular modeling of lectin-like protein from Acacia farnesiana reveals a possible anti-inflammatory mechanism in Carrageenan-induced inflammation.BioMed research international · 2013Article
- Purification and biological activities of Abelmoschus esculentus seed lectin.The protein journal · 2012Article
- Antinociceptive and anti-inflammatory effects of a lectin-like substance from Clitoria fairchildiana R. Howard seeds.Molecules (Basel, Switzerland) · 2012Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selectins are essential for leukocyte recruitment in inflammation. Because of a lectin domain present in the selectin structure, we investigated the anti-inflammtory activity of six mannose-glucose binding lectins from brazilian beans: Dioclea guianensis-DguiL; D. grandiflora-DgL; Cratylia floribunda-CfL; D. violacea-D.vL; D. virgata-DvirL and Canavalia brasiliensis-ConBr. The lectins were injected intravenously (i.v.) into rats (0.1 and 1.0 mg/kg; 30 min before irritants) and its activities compared to E. coli endotoxin (LPS,30 mug/kg i.v.). Three lectins (DvL, CfL and DguiL), although less intense than LPS, inhibited the neutrophil migration induced by carrageenan (Cg, 300 mug) in a dose-dependent manner (0.1 and 1.0 mg/kg). DvL activity was reversed by 0.1 M alpha-D-methyl-mannoside (alpha-CH3), but not by 0.1 M alpha-D-galactose. The fMLP (44 ng)-induced neutrophil migration was also reduced by these lectins. Endotoxin contamination of lectin samples could be excluded since alpha-CH3 treatment reversed the DvL effect, but did not modify LPS inhibitory activity. Carrageenan (300 mug)-induced paw oedema was also reduced by LPS or lectin treatments. Conversely, none of the tested lectins inhibited dextran (Dex, 300 mug)-induced paw oedema, a classical leukocyte independent model, or zymosan (Zy, 1.0 mg)-induced peritonitis and paw oedema. LPS showed no effect upon Dex-induced paw oedema and barely reduced (25%) the oedematogenic effects of zymosan. As proposed for LPS, the lectin inhibitory activity was better observed on neutrophil-mediated inflammatory reactions. We speculate that the plant lectin antiinflammatory activity is probably due to a competitive blockage of a common leukocyte and/or endothelial selectin carbohydrate ligand.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.