ArticleOsteoarthritis and cartilage2008
Characterization of articular calcium-containing crystals by synchrotron FTIR.
Article in Osteoarthritis and cartilage, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 41 citations in OpenAlex.
- TGF-β Enhances Phosphate-Driven Calcification of Human OA Articular Chondrocytes.Calcified tissue international · 2025Article
- Fourier transform infrared spectroscopic imaging of wear and corrosion products within joint capsule tissue from total hip replacements patients.Journal of biomedical materials research. Part B, Applied biomaterials · 2020Article
- Article
- The Therapeutic Potential of Exogenous Adenosine Triphosphate (ATP) for Cartilage Tissue Engineering.Cartilage · 2012Article
- Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage.Arthritis and rheumatism · 2011Article
- Calcium deposition in osteoarthritic meniscus and meniscal cell culture.Arthritis research & therapy · 2010Article
- Articular cartilage vesicles contain RNA.Biochemical and biophysical research communications · 2009Article
- Type II collagen levels correlate with mineralization by articular cartilage vesicles.Arthritis and rheumatism · 2009Article
- Counterpoint: Hydroxyapatite crystal deposition is not intimately involved in the pathogenesis and progression of human osteoarthritis.Current rheumatology reports · 2009Review
- Point: Hydroxyapatite crystal deposition is intimately involved in the pathogenesis and progression of human osteoarthritis.Current rheumatology reports · 2009Article
- Dexamethasone promotes calcium pyrophosphate dihydrate crystal formation by articular chondrocytes.The Journal of rheumatology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveSixty percent of synovial fluids from patients with severe osteoarthritis (OA) contain calcium pyrophosphate dihydrate (CPPD) or basic calcium phosphate (BCP) crystals. These bioactive crystals can be particularly difficult to accurately identify in complex biologic systems, such as in vitro models of crystal formation. We sought to determine if synchrotron Fourier Transform Infrared spectroscopy (sFTIR) could be used to identify and characterize calcium-containing crystals in mineralization models.
methodsCPPD and BCP crystals from porcine models of crystal formation were examined with an FTIR Microscope attached to a synchrotron light source. As a comparison, crystals from human synovial fluids were also examined. The sFTIR spectra generated were compared with known spectra of multiple forms of BCP and CPPD crystals, as well as spectra generated by synthetic CPPD and BCP crystals and cartilage proteoglycans, alone and in mixtures.
resultssFTIR readily identified CPPD and BCP crystals in porcine models as well as in fresh synovial fluids. Brushite was also present in human and porcine samples, and whitlockite was seen in some porcine samples. Mixtures of minerals were commonly found in a single crystal aggregate in both human and porcine samples. In spectra from many CPPD crystals, the peak at the 1134 cm(-1) found on the standard spectrum for CPPD was diminished. Addition of spectra from cartilage proteoglycans to those of synthetic CPPD crystals dampened the peak at this frequency region, much as this peak was diminished in biologically derived CPPD crystals.
conclusionsFTIR analysis allows for accurate identification of CPPD and BCP crystals generated in vitro and will be a useful research tool to study articular crystals.
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