ArticleBehavioural brain research2008
Effect of disconnecting the orbital prefrontal cortex from the nucleus accumbens core on inter-temporal choice behaviour: a quantitative analysis.
Article in Behavioural brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- In praise of the hyperbola.Journal of the experimental analysis of behavior · 2026Review
- Selective chemogenetic inactivation of corticoaccumbal projections disrupts trait choice impulsivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Effects of intra-accumbal administration of dopamine and ionotropic glutamate receptor drugs on delay discounting performance in rats.Behavioral neuroscience · 2017Article
- A framework for understanding and advancing intertemporal choice research using rodent models.Neurobiology of learning and memory · 2017Review
- Effects of N-methyl-D-aspartate receptor ligands on sensitivity to reinforcer magnitude and delayed reinforcement in a delay-discounting procedure.Psychopharmacology · 2017Article
- Neural substrates underlying effort, time, and risk-based decision making in motivated behavior.Neurobiology of learning and memory · 2016Review
- Acute ethanol effects on neural encoding of reward size and delay in the nucleus accumbens.Journal of neurophysiology · 2016Article
- The effect of acute morphine on delay discounting in dependent and non-dependent rats.Psychopharmacology · 2015Article
- Recent Insights into the Neurobiology of Impulsivity.Current addiction reports · 2014Article
- Intake-dependent effects of cocaine self-administration on impulsive choice in a delay discounting task.Behavioral neuroscience · 2014Article
- Do the adjusting-delay and increasing-delay tasks measure the same construct: delay discounting?Behavioural pharmacology · 2014Article
- Partial inactivation of nucleus accumbens core decreases delay discounting in rats without affecting sensitivity to delay or magnitude.Behavioural brain research · 2014Article
- Obesity and addiction: neurobiological overlaps.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2013Review
- The effect of morphine dependence on impulsive choice in rats.Psychopharmacology · 2012Article
- Chronic corticosterone exposure during adolescence reduces impulsive action but increases impulsive choice and sensitivity to yohimbine in male Sprague-Dawley rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Separate prefrontal-subcortical circuits mediate different components of risk-based decision making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Nucleus accumbens and delay discounting in rats: evidence from a new quantitative protocol for analysing inter-temporal choice.Psychopharmacology · 2012Article
- Acute nicotine increases both impulsive choice and behavioural disinhibition in rats.Psychopharmacology · 2011Article
- Effects of selective dopaminergic compounds on a delay-discounting task.Behavioural pharmacology · 2011Article
- Transitional and steady-state choice behavior under an adjusting-delay schedule.Journal of the experimental analysis of behavior · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Previous experiments showed that destruction of the orbital prefrontal cortex (OPFC) or the nucleus accumbens core (AcbC) in rats altered choice between two delayed food reinforcers. Application of a quantitative model of inter-temporal choice suggested that lesions of either structure increased the delay-dependent degradation of reinforcer value (delay discounting); destruction of the OPFC (but not the AcbC) also increased the relative value of the larger reinforcer. This experiment examined the effect of disconnecting the OPFC from the AcbC on inter-temporal choice. Rats received excitotoxin-induced contralateral lesions of the OPFC and AcbC (disconnection), severing of the anterior corpus callosum (callosotomy), a combined lesion (disconnection+callosotomy) or sham lesions. They were trained in a discrete-trials progressive delay schedule to press levers A and B for a sucrose solution. Responses on A delivered 50 microl of the solution after a delay d(A); responses on B delivered 100 microl after a delay d(B). d(B) increased across blocks of trials; d(A) was manipulated across phases of the experiment. Indifference delay, d(B50) (value of d(B) corresponding to 50% choice of B), was estimated for each rat in each phase, and linear indifference functions (d(B50)vs. d(A)) were derived. The disconnection+callosotomy group showed a lower intercept of the indifference function (implying a higher rate of delay discounting) than the sham-lesioned group; the disconnection group showed a similar but less robust effect, whereas the callosotomy group did not differ significantly from the sham-lesioned group. The results suggest that OPFC-AcbC connections are involved in delay discounting of food reinforcers, but provide no evidence for an involvement of OPFC-AcbC connections in regulating sensitivity to reinforcer size.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.