ReviewBiochimie2009
Effect of lactoferrin on enteric pathogens.
Review in Biochimie, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04432935 (Effect of Bovine Lactoferrin on Seroconversion Following Polio Vaccine Administration in Children), which is not on this map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Bovine Lactoferrin on Seroconversion Following Polio Vaccine Administration in Children: A Randomized Control Trial
Who cites it
60 citing papers in PubMed, 153 citations in OpenAlex.
- Mechanisms affecting the gut of preterm infants in enteral feeding trials: a nested cohort within a randomised controlled trial of lactoferrin.Archives of disease in childhood. Fetal and neonatal edition · 2023Trial
- Trial
- Lactoferrin concentration in breast milk of mothers of low-birth-weight newborns.Journal of perinatology : official journal of the California Perinatal Association · 2017Trial
- Growth and tolerance of formula with lactoferrin in infants through one year of age: double-blind, randomized, controlled trial.BMC pediatrics · 2015Trial
- Randomized controlled trial of lactoferrin for prevention of sepsis in peruvian neonates less than 2500 g.The Pediatric infectious disease journal · 2015Trial
- Randomized double-blind controlled trial of bovine lactoferrin for prevention of diarrhea in children.The Journal of pediatrics · 2013Trial
- The Protective and Regenerative Potential of Lactoferrin in Hair and Skin Health.International journal of molecular sciences · 2026Review
- Bacteria-dependent modulation of immune responses in the bovine udder.Veterinary research · 2026Article
- Evaluation of lactoferrin administration as an antibiotic alternative growth promoter: impacts on rabbit's growth, meat quality, blood biochemical parameters, immune status, antioxidant status, and tissue histology.Tropical animal health and production · 2025Article
- Comparative Electrophoretic Analysis Between the Protein Content in Human and Donkey Milk Samples-A Study Covering the Long-Term Lactation Period.Foods (Basel, Switzerland) · 2025Article
- Development and Evaluation of a Nanoparticle-Based Immunoassay for Rotavirus Detection: A Suitable Alternative to ELISA and PCR in Low-Income Setting.Methods and protocols · 2025Article
- Effect of Iron on Viral Infections.Food and environmental virology · 2025Review
- Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer.Molecules (Basel, Switzerland) · 2025Review
- Determination of Bovine Lactoferrin in Powdered Infant Formula and Adult Nutritionals by Heparin Affinity Extraction and Reverse-Phase High-Performance Liquid Chromatography/Ultraviolet Detection (HPLC/UV): Single-Laboratory Validation, First Action 2021.10.Journal of AOAC International · 2024Article
- Lactoferrin impairs pathogen virulence through its proteolytic activity.Frontiers in veterinary science · 2024Review
- Lactoferrin for the postoperative management of term neonates after gastrointestinal surgery.The Cochrane database of systematic reviews · 2023Review
- Antibacterial, Antifungal, and Anticancer Effects of Camel Milk Exosomes: An In Vitro Study.Veterinary sciences · 2023Article
- Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Much has been learned in recent years about the mechanisms by which breastfeeding improves child health and survival. However, there has been little progress in using these insights to improve pediatric care. Factors that are important for protecting the breast fed infant might be expected to decrease the adverse effects of weaning on diarrhea, growth, and development. Lactoferrin, an iron-binding protein with multiple physiological functions (anti-microbial, anti-inflammatory, and immunomodulatory), is one of the most important proteins present in mammalian milk. Protection against gastroenteritis is the most likely biologically relevant activity of lactoferrin. Multiple in vitro and animal studies have shown a protective effect of lactoferrin on infections with enteric microorganisms, including rotavirus, Giardia, Shigella, Salmonella and the diarrheagenic Escherichia coli. Lactoferrin has two major effects on enteric pathogens: it inhibits growth and it impairs function of surface expressed virulence factors thereby decreasing their ability to adhere or to invade mammalian cells. Thus, lactoferrin may protect infants from gastrointestinal infection by preventing the attachment by enteropathogens in the gut. Recently several clinical trials in children have started to address this issue. Whether lactoferrin can prevent a significant portion of diarrheal disease remains to be determined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.