ArticleNeurobiology of aging2010
The effects of healthy aging on intracerebral blood vessels visualized by magnetic resonance angiography.
Article in Neurobiology of aging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 110 citations in OpenAlex.
- Cerebral vasomotor reactivity during hypo- and hypercapnia across the adult lifespan.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
- White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial.Journal of Alzheimer's disease : JAD · 2020Trial
- Uncertainty-aware automated labeling of intracranial arteries using deep learning.BMC medical imaging · 2026Article
- Regional brain and cerebrovasculature morphology during normative aging in male and female C57BL/6N mice.Frontiers in aging neuroscience · 2026Article
- Age-related variations of the hemodynamic response function spatially resolved across human cerebral cortex.Frontiers in aging neuroscience · 2026Article
- Accurate and fully automated diameter measurements of Circle of Willis arteries on MRA imaging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Functional MRI signatures of autonomic physiology in aging.Communications biology · 2025Article
- Cerebrovascular morphology: Insights into normal variations, aging effects and disease implications.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Review
- Machine Learning-Based Age Prediction with Feature Subset Selection from Magnetic Resonance Angiography Data.Healthcare informatics research · 2025Article
- Vessels hiding in plain sight: quantifying brain vascular morphology in anatomical MR images using deep learning.bioRxiv : the preprint server for biology · 2025Article
- Functional MRI Signatures of Autonomic Physiology in Aging.bioRxiv : the preprint server for biology · 2025Article
- Article
- The Role and Mechanism of Vascular Aging in Geriatric Vascular Diseases.Aging and disease · 2024Review
- Assessing Machine Learning Models for Predicting Age with Intracranial Vessel Tortuosity and Thickness Information.Brain sciences · 2023Article
- GDF11 and aging biology - controversies resolved and pending.The journal of cardiovascular aging · 2023Article
- The Brain and Spinal Microvasculature in Normal Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Review
- A framework of biomarkers for vascular aging: a consensus statement by the Aging Biomarker Consortium.Life medicine · 2023Article
- Vascular tortuosity is related to reduced thalamic volume after middle cerebral artery occlusion.Heliyon · 2023Article
- End to end stroke triage using cerebrovascular morphology and machine learning.Frontiers in neurology · 2023Article
- Volumetric Characterization of Microvasculature in Ex Vivo Human Brain Samples By Serial Sectioning Optical Coherence Tomography.IEEE transactions on bio-medical engineering · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Histological and magnetic resonance imaging studies have demonstrated that age-associated alterations of the human brain may be at least partially related to vascular alterations. Relatively little information has been published on vascular changes associated with healthy aging, however. The study presented in this paper examined vessels segmented from standardized, high-resolution, magnetic resonance angiograms (MRAs) of 100 healthy volunteers (50 males, 50 females), aged 18-74, without hypertension or other disease likely to affect the vasculature. The subject sample was divided into 5 age groups (n=20/group) with gender equally distributed per group. The anterior cerebral, both middle cerebral, and the posterior circulations were examined for vessel number, vessel radius, and vessel tortuosity. Males exhibited larger vessel radii regardless of age and across all anatomical regions. Both males and females displayed a lower number of MRA-discernible vessels with age, most marked in the posterior circulation. Age-associated tortuosity increases were relatively mild. Our multi-modal image database has been made publicly available for use by other investigators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.