SynthesisArthritis research & therapy2008
Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis.
Synthesis in Arthritis research & therapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 17 citations in OpenAlex.
- Functional Diversity and Emerging Roles of Human NME/NDPK Group II Proteins.International journal of molecular sciences · 2026Review
- Molecular mechanisms and genetic factors contributing to the developmental dysplasia of the hip.Frontiers in genetics · 2024Review
- Genetic characterization of Macaca arctoides: A highlight of key genes and pathways.Primates; journal of primatology · 2023Article
- Rho GTPase signaling in rheumatic diseases.iScience · 2022Review
- Comprehensive analysis of theTranslational cancer research · 2020Article
- Association study of candidate genes for susceptibility to Kashin-Beck disease in a Tibetan population.BMC medical genetics · 2017Article
- A novel missense variant inInternational journal of clinical and experimental pathology · 2017Article
- Genes associated with Alzheimer's disease: an overview and current status.Clinical interventions in aging · 2016Review
- The effect of the top 20 Alzheimer disease risk genes on gray-matter density and FDG PET brain metabolism.Alzheimer's & dementia (Amsterdam, Netherlands) · 2016Article
- Update on basic and clinical aspects of osteoarthritis.Annals of translational medicine · 2015Article
- Association of single nucleotide polymorphisms in estrogen receptor alpha gene with susceptibility to knee osteoarthritis: a case-control study in a Chinese Han population.BioMed research international · 2014Article
- Late-Onset Alzheimer's Disease Genes and the Potentially Implicated Pathways.Current genetic medicine reports · 2014Review
- Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy.Arthritis research & therapy · 2013Review
- Genetic polymorphism of PITX1 in susceptibility to knee osteoarthritis in a Chinese Han population: a case-control study.Rheumatology international · 2011Article
- Genetic epidemiology of hip and knee osteoarthritis.Nature reviews. Rheumatology · 2011Review
- Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes.Journal of cellular biochemistry · 2010Review
- Lack of association between the CALM1 core promoter polymorphism (-16C/T) and susceptibility to knee osteoarthritis in a Chinese Han population.BMC medical genetics · 2008Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionConflicting findings on the association of single nucleotide polymorphisms (SNPs) in RHOB and TXNDC3 with susceptibility to knee osteoarthritis (OA) have been reported in European Caucasians. To examine the associations of these SNPs with OA in East Asian populations and to evaluate their global significance, we conducted two case-control studies in 955 Chinese and 750 Japanese patients.
methodsWe genotyped the previously implicated SNPs rs585017 (in RHOB) and rs4720262 (in TXNDC3) in patients with primary symptomatic knee OA with radiographic confirmation and in matched control individuals, and analyzed their associations. We further conducted a meta-analysis of the study findings together with those of previously reported European studies using the DerSimonian-Laird procedure.
resultsA significant association of RHOB with knee OA was observed in male Chinese patients (P = 0.02). No significant associations were found for RHOB in any other comparisons in the East Asian populations. The association of TXNDC3 was replicated in Chinese female (P = 0.04) and Japanese (P = 0.03) patients, although none of these associations persisted after Bonferroni correction. Significant association (P = 0.02 for the allelic frequency) with nonsignificant heterogeneity was found in the East Asian replication study. No significant association was found in any comparison in the meta-analysis for all studies.
conclusionOur study replicates the association, previously reported in European Caucasians, of TXNDC3 with knee OA susceptibility in an East Asian population.
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