Trial reportThe Journal of infectious diseases2008
A trial of the effect of micronutrient supplementation on treatment outcome, T cell counts, morbidity, and mortality in adults with pulmonary tuberculosis.
Trial report in The Journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00197704 (Nutrition, Immunology and Epidemiology of Tuberculosis), which is not on this map. Cited by 47 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nutrition, Immunology and Epidemiology of Tuberculosis
Who cites it
47 citing papers in PubMed, 10 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Effectiveness of nutritional support to improve treatment adherence in patients with tuberculosis: a systematic review.Nutrition reviews · 2024Pooled it
- Effects of zinc and vitamin A supplementation on prognostic markers and treatment outcomes of adults with pulmonary tuberculosis: a systematic review and meta-analysis.BMJ global health · 2022Pooled it
- Anemia, Iron Status, and HIV: A Systematic Review of the Evidence.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Micronutrient supplementation in adults with HIV infection.The Cochrane database of systematic reviews · 2017Pooled it
- Nutritional supplements for people being treated for active tuberculosis.The Cochrane database of systematic reviews · 2016Pooled it
- Adjuvant Efficacy of Nutrition Support During Pulmonary Tuberculosis Treating Course: Systematic Review and Meta-analysis.Chinese medical journal · 2015Pooled it
- Micronutrients in HIV: a Bayesian meta-analysis.PloS one · 2015Pooled it
- Pooled it
- Micronutrient supplementation in pregnant women with HIV infection.The Cochrane database of systematic reviews · 2012Pooled it
- Vitamin D for treatment and prevention of infectious diseases: a systematic review of randomized controlled trials.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsPooled it
- Vitamin A and D Deficiencies Associated With Incident Tuberculosis in HIV-Infected Patients Initiating Antiretroviral Therapy in Multinational Case-Cohort Study.Journal of acquired immune deficiency syndromes (1999) · 2017Trial
- The effect of neonatal vitamin A supplementation on morbidity and mortality at 12 months: a randomized trial.International journal of epidemiology · 2016Trial
- Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania.Epidemiology and infection · 2014Trial
- Trial
- Iron status predicts treatment failure and mortality in tuberculosis patients: a prospective cohort study from Dar es Salaam, Tanzania.PloS one · 2012Trial
- Zinc and vitamin A supplementation fails to reduce sputum conversion time in severely malnourished pulmonary tuberculosis patients in Indonesia.Nutrition journal · 2010Trial
- Food incentives to improve completion of tuberculosis treatment: randomised controlled trial in Dili, Timor-Leste.BMJ (Clinical research ed.) · 2009Trial
- Insights from selenoprotein I mouse models for understanding biological roles of this enzyme.Archives of biochemistry and biophysics · 2025Review
- Micronutrient status and risk of Mycobacterium tuberculosis infection in Indonesian tuberculosis case contacts.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2025Article
- A scoping review of interventions to prevent and treat adverse events during treatment of rifampin-susceptible tuberculosis.PloS one · 2025Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundTuberculosis (TB) often coincides with nutritional deficiencies. The effects of micronutrient supplementation on TB treatment outcomes, clinical complications, and mortality are uncertain.
methodsWe conducted a randomized, double-blind, placebo-controlled trial of micronutrients (vitamins A, B complex, C, and E, as well as selenium) in Dar es Salaam, Tanzania. We enrolled 471 human immunodeficiency virus (HIV)-infected and 416 HIV-negative adults with pulmonary TB at the time of initiating chemotherapy and monitored them for a median of 43 months.
resultsMicronutrients decreased the risk ofTB recurrence by 45% overall (95% confidence interval [CI], 7% to 67%; P = .02) and by 63% in HIV-infected patients (95% CI, 8% to 85%; P = .02). There were no significant effects on mortality overall; however, we noted a marginally significant 64% reduction of deaths in HIV-negative subjects (95% CI, -14% to 88%; P = .08). Supplementation increased CD3+ and CD4+ cell counts and decreased the incidence of extrapulmonary TB and genital ulcers in HIV-negative patients. Micronutrients reduced the incidence of peripheral neuropathy by 57% (95% CI, 41% to 69%; P < .001), irrespective of HIV status. There were no significant effects on weight gain, body composition, anemia, or HIV load.
conclusionsMicronutrient supplementation could improve the outcome in patients undergoing TB chemotherapy in Tanzania.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.